Inflammation and Cancer: Triggers, Mechanisms and Consequences
By F. Greten, S. Grivennikov. Immunity, 2019
3,133 citations recorded by the source corpus.
Summary Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are highly plastic, continuously changing their phenotypic and functional characteristics. Here we review the origins of inflammation in tumors, and the mechanisms whereby inflammation drives tumor initiation, growth, progression and metastasis. We discuss how tumor promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis or tissue repair, and illuminate the distinctions between tissue-protective and pro-tumorigenic inflammation, including spatio-temporal considerations. Defining the cornerstone rules of engagement governing molecular and cellular mechanisms of tumor-promoting inflammation will be essential for the further development of anti-cancer therapies.
Subfields: Immunology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/e73744ef8926095e96e04e9e17b59180c296290f
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Citations in the corpus
- CellViT: Vision Transformers for Precise Cell Segmentation and Classification (2023, background): “One crucial component is the analysis of the cells and their distribution within the tissue, such as detecting tumor-infiltrating lymphocytes [2] or inflammatory cells in the tumor microenvironment [3, 4].”
- Role of Glutathione in Cancer: From Mechanisms to Therapies (2020, background): “A detailed review of many roles of the inflammation-driven changes in tumorigenesis has been recently provided [102].”
- Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs (2022, background): “There are studies proving that, among many others, chronic inflammation state is directly connected with cancer development in different cells and tissues [223,224].”
- Pattern recognition receptors in health and diseases (2021, background): “PRR-RELATED DISEASES PRRs and cancers The inflammatory microenvironment of tumor constitutes the barrier for tumor growth, which is conducive to tumor formation and development.(309) PRRs are widely expressed in a variety of tumor tissues, such as colon cancer, lung cancer, breast cancer, gastric ca”
- Ferroptosis in infection, inflammation, and immunity (2021, background): “Tumorigenesis and therapy Inflammation is a double-edged sword in tumor immunity (Greten and Grivennikov, 2019).”