A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline

By Vasily V. Vagin, A. Sigova, Chengjian Li, Hervé Seitz, V. Gvozdev, Phillip D. Zamore. Science, 2006

1,381 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/5dd19ef85ed91a016b5f0f65a31925711cc9edd8

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Citations in the corpus

Human tRNA-derived small RNAs in the global regulation of RNA silencing. (2010, background): “…to the microRNA flanked on both sides by small hairpins and that had been reported to be more efficient than simple antisense for microRNA inhibition (Vermeulen et al. 2007), increased reporter gene activity by over fivefold compared to a control inhibitor directed against miR-20 (Fig.”
Discovering microRNAs from deep sequencing data using miRDeep (2008, background): “Some genomes transcribe short functional noncoding transcripts, such as endogenous small interfering RNAs or repeat-associated interfering RNA”
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. (2007, background): “Drosophila Piwi proteins interact with small RNAs of 24–26 nucleotides in length (Aravin et al., 2001; Saito et al., 2006; Vagin et al., 2006).”
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation (2012, neutral): “They lack the 3’-end modification and they originate from fragmentation of longer transcripts in a Dicer-independent manner (Brennecke et al., 2007; Vagin et al., 2006; Thomson and Lin, 2009).”
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. (2007, methodology): “In Drosophila, a role in both the somatic germline as well as in the germ cells has been identified (Cox et al., 1998, 2000).”
Biogenesis of small RNAs in animals (2009, background): “Intriguingly, the biogenesis of piRNAs does not depend on Dice”
Small silencing RNAs: an expanding universe (2009, neutral): “Later, these 'repeat associated small interfering RNAs' — subsequently renamed piRNAs — were found to be distinct from siRNAs: they bind Piwi proteins and do not require DCR-1 or DCR-2 for their production, unlike miRNAs and siRNA”
Argonaute proteins: key players in RNA silencing (2008, background): “and are required to silence mobile elements and thereby maintain genome integrit”