Cell type-specific involvement of RIG-I in antiviral response.
By H. Kato, Shintaro Sato, Mitsutoshi Yoneyama, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, T. Tsujimura, K. Takeda, T. Fujita, O. Takeuchi and 1 more. Immunity, 2005
1,465 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/5dbba6bd1e6841fee6f9549e38f050b7e91858be
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Shizuo Akira
- Taro Kawai
- R. Medzhitov
- O. Takeuchi
- Zhijian J. Chen
- Daniel B. Stetson
- T. Mogensen
- Satoshi Uematsu
In Oncology
- Shizuo Akira
- R. Medzhitov
- O. Takeuchi
- Daniel B. Stetson
- Taro Kawai
- Satoshi Uematsu
- Anna Marie Pyle
- Zhijian J. Chen
Citations in the corpus
- Innate Immunity to Virus Infection (2009, background): “Although RLRs play essential roles in the production of type I IFNs and cytokines in various cell types, such as fibroblasts and cDCs, pDCs produce these cytokines in the absence of RLR signaling (14).”
- A minimal RNA ligand for potent RIG-I activation in living mice (2017, background): “We were unable to examine the RIG-I–deficient mice due to embryonic lethality (39).”
- Novel Markers to Delineate Murine M1 and M2 Macrophages (2015, background): “Stat activity has been linked to increased expression of Dead Box Polypeptide (Ddx) 58 [29,43], a putative helicase implicated in RNA binding.”
- Toll-like receptors and innate immunity (2006, background): “Furthermore, the RNA helicase, retinoic acid inducible gene-I (RIG-I), was identified as a cytosolic receptor for intracellular double-stranded (dsRNA) [5] and induces type I interferons (IFNs) in response to dsRNA viruses in a TLR-independent manner [6].”
- Type I interferons in host defense. (2006, positive): “Interestingly, pDC-derived type I IFN production in response to these viruses requires MyD88-dependent TLR signaling but not RIG-I, highlighting the fact that TLRs and cytosolic sensors can independently activate type I IFNs in vivo (Kato et al., 2005).”
- IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction (2005, background): “Consistent with that, RIG-I-deficient mice fail to produce type I interferon in response to infection by vesicular stomatitis virus (VSV), Newcastle disease virus (NDV) and Sendai viru”
- Cytosolic Sensing of Viruses (2013, background): “Interestingly, the first RIG-Ideficient mouse strain generated showed liver degeneration and embryonic lethality at day 12.5, suggesting that RIG-I could be involved in development (Kato et al., 2005).”
- Programming the magnitude and persistence of antibody responses with innate immunity (2011, neutral): “vector RIG 0 2 4 6 vector KLm (1-1012) KLs (1-549) KLsss (34-549)”