IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

By Taro Kawai, Ken Takahashi, Shintaro Sato, C. Coban, Himanshu Kumar, H. Kato, K. Ishii, O. Takeuchi, Shizuo Akira. Nature Immunology, 2005

2,715 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/6315f3f25318bfc071261d6dab12b1295e04fcee

How researchers see this paper

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. Zhijian J. Chen
4. R. Medzhitov
5. O. Takeuchi
6. S. Ghosh
7. T. Mogensen
8. M. Hayden

In Oncology

1. Shizuo Akira
2. R. Medzhitov
3. O. Takeuchi
4. Taro Kawai
5. Daniel B. Stetson
6. M. Karin
7. S. Ghosh
8. Satoshi Uematsu

Citations in the corpus

• Programming the magnitude and persistence of antibody responses with innate immunity (2011, neutral): “vector RIG 0 2 4 6 vector KLm (1-1012) KLs (1-549) KLsss (34-549)”
• RIG-I dependent sensing of poly(dA-dT) via the induction of an RNA polymerase III transcribed RNA intermediate (2009, positive): “Both RIG-I and Mda5 engage the mitochondrial adaptor protein IPS-1 (also known as MAVS, Cardif or VISA”
• 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I (2009, background): “RIG-I and MDA5 also contain N-terminal tandem caspase activation and recruitment domains (CARD), which interact with the CARD domain of mitochondrial antiviral signaling protein (MAVS, also known as IPS-1, VISA, and CARDIF) (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005”
• RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “The involvement of Fas-associated death domain (FADD) and receptor interacting protein 1 (RIP1), which are both death domain (DD)-containing molecules, in the IPS-1 signaling complex was demonstrated (65, 82).”
• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “The novel protein is required to mediate RIG-I and MDA5 signals to downstream factors and is therefore called either IPS-1 for ‘‘interferon-hpromoter stimulator 1’’ (Kawai et al., 2005) or MAVS for ‘‘mitochondrial antiviral signaling’’ molecule (Seth et al., 2005).”
• Pathogen recognition and innate immunity. (2006, positive): “Recently, expression cloning studies have identified IPS-1, an adaptor protein composed of an N-terminal CARD domain resembling that of MDA-5 or RIG-I (Kawai et al., 2005).”