MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder.

By J. Bremner, M. Vythilingam, E. Vermetten, S. Southwick, T. Mcglashan, A. Nazeer, Sarfraz Khan, L. Viola Vaccarino, R. Soufer, Pradeep K. Garg and 4 more. American Journal of Psychiatry, 2003

712 citations recorded by the source corpus.

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Citations in the corpus

The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “…volumes can explain abnormal hippocampal activation in PTSD is not entirely clear, although the findings of at least two studies suggest that functional abnormalities might be still present even if the volumetric differences are controlled statistically (Bremner et al, 2003a; Shin et al, 2004b).”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, result): “Most [118,122] but not all [123] studies reported smaller hippocampus volume in adult patients with maltreatment-related PTSD versus healthy controls, leading to meta-analytic evidence of smaller hippocampus volume in this population [76].”
The Neural Basis of the Dynamic Unconscious (2011, background): “Early life exposure to elevated glucocorticoid levels, released during stress, may result in progressive hippocampal (a target for glucocorticoids) atrophy (Bremner et al., 2003; Stein, Koverola, Hanna, Torchia, & McClarty, 1997).”
Source monitoring 15 years later: What have we learned from fMRI about the neural mechanisms of source memory? (2009, background): “…the downside of the Yerkes–Dodson arousal curve: In some early PET studies, PTSD patients showed less hippocampal activity (even after controlling for reduced volume) than did controls during encoding of emotional paragraphs and also during the recall of emotional word pairs (Bremner et al., 2003).”
Research review: the neurobiology and genetics of maltreatment and adversity. (2010, background): “, 2005) have compared women survivors of childhood sexual abuse with and without PTSD (Bremner et al., 1999; Bremner et al., 2003; Bremner, Vythilingam, Vermetten, Vaccarino, & Charney, 2004).”
Neurobiological and psychiatric consequences of child abuse and neglect. (2010, background): “Bremner et al. (2003) reported a relationship between hippocampal volume and function and PTSD associated with early-life sexual abuse.”
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future. (2006, background): “Together, these results also support the model of hippocampal dysfunction in PTSD. Interestingly, the findings of Shin et al (2004a) indicate elevated baseline hippocampal activity in PTSD, along with attenuated capacity for activation when called upon.”
A meta-analysis of structural brain abnormalities in PTSD. (2006, background): “…evidence from neuroimaging research suggests that this altered information processing is associated with differential functional neuroanatomical activity in PTSD (Bremner et al., 1999b, 2003b; Clark et al., 2003; Matsuo et al., 2003; Rauch et al., 1996; Shaw et al., 2002; Shin et al., 2004a, b).”
Neuroimaging of child abuse: a critical review (2012, methodology): “…the changes are marked enough, can lead to the development of PTSD and other psychiatric conditions, as suggested by studies that report changes in brain structure in survivors of childhood maltreatment without PTSD and more marked changes in abuse survivors with PTSD (e.g., Bremner et al., 2003).”
Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus (2007, background): “Second, among individuals with post-traumatic stress disorder, longer-term exposure to traumatic events beginning earlier in life also predicts a decreased volume of the hippocampus (Bremner et al., 2003; Gurvits et al., 1996; Kitayama et al., 2005; Vythilingam et al., 2002).”
Health Outcomes by Closeness of Sexual Abuse Perpetrator: A Test of Betrayal Trauma Theory (2012, background): “Victims of childhood abuse are significantly more likely than nonvictims to suffer from depression (Koverola, Pound, Heger, & Lytle, 1993; Mannarino, Cohen, & Berman, 1994; Molnar, Buka, & Kessler, 2001) and anxiety (Mancini, Van Ameringen, & MacMillan, 1995); and to manifest psychiatric syndromes s”