The superfamily of organic anion transporting polypeptides.

By B. Hagenbuch, P. Meier. Biochimica et Biophysica Acta, 2003

864 citations recorded by the source corpus.

Subfields: Biochemistry, Clinical Biochemistry, Oncology

View Paper: https://www.semanticscholar.org/paper/5d17749d71cb5fd9f1787653b1b1b86047de0699

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Citations in the corpus

Membrane transporters in drug development (2010, background): “The mechanism of transport appears to consist of anion exchange by coupling the cellular uptake of substrate with the efflux of endogenous intracellular substances such as bicarbonate in a process that seems to be electroneutra”
A review of cyanobacterial odorous and bioactive metabolites: Impacts and management alternatives in aquaculture (2008, background): “OATPs are responsible for the active membrane transport of bile acids, steroids, and various peptides (Hagenbuch and Meier, 2003).”
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “A large extracellular domain is thought to be located between transmembrane domains 9 and 10, with N-glycosylation sites present in extracellular loops 2 and 5 (Hagenbuch and Meier, 2003).”
Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake (2011, background): “OATP1B1 is a 691-amino acid glycoprotein; it contains, on the basis of hydropathy analyses, 12 putative membrane-spanning domains and a large fifth extracellular loop (König et al., 2000b; Hagenbuch and Meier, 2003; Chang et al., 2005; Niemi, 2007) (Fig.”
Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability (2004, background): “, 1990) except those targeted to transporters/receptors capable of anionic molecule transport and/or endocytosis (Hagenbuch and Meier, 2003).”
Bile Formation and Secretion (2013, neutral): “…carriers polypeptides (OATPs) (418, 469) OATP/Oatps have broad substrate speciﬁcity and facilitate sodium-independent hep-atic uptake of many different organic amphipathic compounds without respect to structure or electrical charge that are primarily large hydrophilic organic anions (206,208,209).”
Impact of OATP transporters on pharmacokinetics (2009, background): “The human OATP family consists of 11 members: OATP1A2, 1B1, 1B3, 1C1, 2A1, 2B1, 3A1, 4A1, 4C1, 5A1 and 6A1 (Hagenbuch and Meier, 2003; Mikkaichi et al., 2004a; König et al., 2006) (Table 1).”
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. (2006, neutral): “Bromosulphopthalein, para-aminohippuric acid, taurocholic acid, cholic acid, and estrone-3-sulfate, substrates for organic anion solute carriers (SLC21 and SLC 22) (Hagenbuch and Meier, 2003; Koepsell and Endou, 2004), did not inhibit [ 3 H]folic acid influx.”
Blood-brain barrier drug targeting: the future of brain drug development. (2003, background): “Candidates for the sodium-independent exchangers at the BBB include organic anion–transporting polypeptide type 2 (oatp2) (33, 34), or BBB specific anion transporter type 1 (BSAT1) (35), which is also a member of the oatp family and is designated oatp14 (36).”
Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties (2004, methodology): “Further details about the molecular and functional properties of this transporter superfamily can be found in our previous review [1].”