Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties

By B. Hagenbuch, P. Meier. Pflügers Archiv, 2004

1,054 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ba94fe200ca033f947f0149600b6bb32e2ee280e

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In Biochemistry

1. J. L. Boyer
2. C. Klaassen
3. Lauren M. Aleksunes
4. M. Niemi
5. M. Roth
6. A. Obaidat
7. A. Kalliokoski
8. B. Hagenbuch

In Molecular Biology

1. J. L. Boyer
2. C. Klaassen
3. Lauren M. Aleksunes
4. M. Roth
5. A. Obaidat
6. A. Ramachandran
7. M. Niemi
8. Christoph Borner

In Oncology

1. J. L. Boyer
2. Lauren M. Aleksunes
3. C. Klaassen
4. M. Niemi
5. M. Roth
6. A. Obaidat
7. A. Kalliokoski
8. P. Neuvonen

Citations in the corpus

• Impact of OATP transporters on pharmacokinetics (2009, background): “OATPs are encoded by genes of the SLCO family (previously SLC21) (Hagenbuch and Meier, 2004).”
• Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications (2007, background): “Agmatine (24,000) 1,400 (3,251) 2,500 (106) Ergothioneine 21 (108) Stachydrine 270 (108)”
• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, methodology): “31 NM_178859 OST ET, ergothioneine transporter; NKT, novel kidney transporter; NLT, novel liver transporter; Roct, reduced in osteosclerosis transporter; IBAT/ISBT, ileal sodiumdependent bile acid cotransporter; RST, renal-specific transporter; SPNT, sodium-dependent purine nucleoside transporter. a”
• Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake (2011, background): “…OATP1B1, but according to one study using three-dimensional quantitative structure-activity relationship models, OATP1B1 substrates produce a pharmacophore containing two hydrogen bond acceptors, one hydrogen bond donor, and two hydrophobic regions (Hagenbuch and Meier, 2004; Chang et al., 2005).”
• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “BAs are then taken up by hepatocytes from portal blood via the Na -taurocholic acid cotransporting polypeptide (NTCP or Slc10a1), which has a substrate specificity essentially limited to conjugated BAs (102), or by Na -independent systems represented by members of the superfamily of organic anion tr”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “Eleven human OATPs have been identified so far, which have been classified into six families according to their amino acid identity (Hagenbuch and Meier 2004; Mikkaichi et al. 2004; Hagenbuch and Gui 2008).”
• Bile Formation and Secretion (2013, positive): “OATP1B1 and 1B3 are hepatocyte specific and functionally the most important (210,300,418).”
• OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies (2012, methodology): “This superfamily was originally named SLC21A; however, the nomenclature of its members was updated and standardized in 2004 based on phylogenetic relationships, and the superfamily was renamed to SLCO, the solute carrier family of the OATPs (Hagenbuch and Meier, 2004).”