Blood-brain barrier drug targeting: the future of brain drug development.

By W. Pardridge. Molecular Interventions, 2003

694 citations recorded by the source corpus.

Subfields: Biochemistry, Oncology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/736cbd8d04262cc1e6d1519a3dddd32acf5ec5b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. P. Vlieghe
2. M. Khrestchatisky
3. R. Gabathuler

In Oncology

1. P. Vlieghe
2. Behnam Noorani
3. Amanda F. Levy
4. Mao Ye
5. Peter C. Searson
6. Jeffrey D. Rothstein
7. M. Khrestchatisky
8. L. Cucullo

In Pediatrics, Perinatology and Child Health

1. P. Vlieghe
2. Behnam Noorani
3. M. Khrestchatisky
4. L. Cucullo
5. Hossam Kadry
6. R. Gabathuler

Citations in the corpus

• A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity (2020, background): “One of the most potent BBB molecular Trojan horses is a mAb for the human insulin receptor (HIR), which is active at both the BBB of humans and Old-World primates such as Rhesus monkeys [147].”
• Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. (2010, methodology): “Both the chimeric antibody and a fully humanized form of the 83-14 antibody against HIR have been created (Boado et al., 2007) and shown to be able to transport an associated/conjugated molecule across the BBB. Antibodies against TR and HIR for brain drug targeting Applications of these antibodies t”
• 3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Furthermore, the BBB regulates active and passive transport of solutes into the brain [9,10], posing an obstacle to drug delivery for the treatment of neurological diseases and brain tumors [11,12].”
• Medicinal Chemistry Based Approaches and Nanotechnology‐Based Systems to Improve CNS Drug Targeting and Delivery (2013, background): “Location of barrier sites in the central nervous system (CNS): (1) the brain endothelium that forms the blood–brain barrier (BBB); (2) the arachnoid epithelium that forms the middle layer of the meninges; and (3) the choroid plexus epithelium, which secretes the cerebrospinal fluid (CSF), reprinted ”
• The blood-brain barrier: an engineering perspective (2013, background): “The barrier function of the BBB is critical for regulating transport to the brain, but also represents a significant roadblock in delivering drugs to the brain (Pardridge, 2003, 2005, 2006, 2008, 2010; Hawkins and Davis, 2005; Ohtsuki and Terasaki, 2007).”