Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.

By A. Qiu, M. Jansen, A. Sakaris, S. Min, S. Chattopadhyay, Eugenia Tsai, C. Sandoval, R. Zhao, M. Akabas, I. Goldman. Cell, 2006

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Homeostasis and toxicology of essential metals (2012, background): “Currently, there is debate over the presence of an intestinal heme transporter, with the candidate protein slc46a1 (heme carrier protein 1) (Shayeghi et al., 2005) being a potential folate transporter (Qiu et al., 2006; Laftah et al., 2009).”
Biomarkers of Nutrition for Development-Folate Review. (2015, background): “· THF polyglutamates must be hydrolyzed to THF monoglutamates in the gastrointestinal tract before absorption across the intestinal epithelium of the duodenum by the PCFT (116).”
Is folic acid good for everyone? (2008, background): “Transport of unmetabolized folic acid into cells can also occur via the folate receptor, as well as by several transporters (20), but little is known about the intracellular effects of folic acid itself.”
Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken (2007, background): “PTU treatment repressed expression of THRSP (a thyroid hormone responsive transcription factor) (Wang et al., 2004), a Na+/glucose symporter (MFSD2) (Spinola et al., 2007) and a folate transporter (SLC19A1) (Qiu et al., 2006).”
Systemic iron homeostasis. (2013, background): “Although the molecule is clearly capable of transporting heme, it later turned out to transport folate and to be mutated in patients with genetic folate deficiency (195), indicating that its nonredundant function was folate uptake in the duodenum.”