Rho and Rac take center stage.

By K. Burridge, Krister Wennerberg. Cell, 2004

1,866 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5cd4f2d013326f6046c8c737989321ae292df978

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Citations in the corpus

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “specific effects to the actin cytoskeleton.(14,15) Of these, RhoA, -B, and -C comprise the Rho subgroup of Rho GTPases, which have redundant functions and from here on will be discussed simply with respect to findings regarding RhoA.”
Synergistic control of cell adhesion by integrins and syndecans (2007, background): “Adhesion to the ECM regulates numerous signalling pathways, including those that involve Rho-family GTPase”
The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006, neutral): “Radisky reported that MMP-3 activates EMT by inducing the production of an alternatively spliced variant of Rac1, which is a small GTPase that regulates cell migration through control of actin polymerization ( Burridge and Wennerberg, 2004 ).”
Local force and geometry sensing regulate cell functions (2006, background): “In support of this proposition, Rac activation is known to enhance focal-complex assembl”
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. (2008, background): “The Rho/ROCK pathway is involved in oxidative stress, aortic stiffness and changes in blood pressure [49].”
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells (2009, background): “FAK in turn also mediates other pathways such as RhoA, which stimulates the actomyosin contraction [29] and proliferation, [30], and Rac1, which regulates lamellipodia formation [31].”
Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken (2007, background): “CDC42EP1 is a binding protein, which inactivates CDC42, a major GTPase that regulates cell polarity, motility and proliferation (Schmitz et al., 2000; Burridge and Wennerberg, 2004; Etienne-Manneville, 2004; Jaffe and Hall, 2005; Fidyk et al., 2006).”
The role of the Rho GTPases in neuronal development. (2005, background): “…reviews on Rho effectors, the reader is referred to the following references: Van Aelst and D’Souza-Schorey (1997); Bishop and Hall (2000); Gundersen (2002); Luo (2002); Bokoch (2003); Miki and Takenawa (2003); Riento and Ridley (2003); Burridge and Wennerberg (2004); Millard et al. (2004).”
Rho kinase, a promising drug target for neurological disorders (2005, background): “RhoGTPases, a subfamily of the Ras superfamily of GTPases, function as molecular devices that control multiple signalling pathways in a very precise and coordinated way by switching between a biochemically inactive (GDP-bound) and an active (GTP-bound) stat”
Adhesion signaling – crosstalk between integrins, Src and Rho (2009, background): “Phosphorylated growth-factor receptors control RhoGTPases through direct interactions with GEFs or GAPs, or through indirect mechanisms such as activation of phosphatidylinositol 3- kinase (PI3K) (Burridge and Wennerberg, 2004).”
Environmental sensing through focal adhesions (2009, background): “The master regulators of essentially every aspect of actin cytoskeleton function are the small Rho family GTPases, principally Rho and Ra”