PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain

By T. Rohacs, Coeli M. B. Lopes, I. Michailidis, D. Logothetis. Nature Neuroscience, 2005

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An introduction to TRP channels. (2006, background): “It is presently unclear why PIP2 appears to stimulate some TRP channels (TRPV5, TRPM5, TRPM7, TRPM8) (22, 24) while inhibiting others (TRPV1) (25, 26).”
PIP2 is a necessary cofactor for ion channel function: how and why? (2008, background): “For TRPM8 and TRPM4, PIP2 shifts the voltage range of activation toward negative potentials (54, 70).”
Attenuated cold sensitivity in TRPM8 null mice. (2007, neutral): “Analogous to TRPV1 and TRPA1, activation of TRPM8 by menthol or icilin is modulated by certain inflammatory mediators, such as protons, phospholipids, and bradykinin (Andersson et al., 2004; Premkumar et al., 2005; Rohacs et al., 2005).”
TRP Channels (2012, neutral): “TRPM8 undergoes Ca2+-dependent desensitization, which has been attributed to breakdown of PIP2, which has an activating effect on the channel (357).”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “For example, inositol lipid regulation was mapped to the TRP domains of the cytoplasmic tails of TrpM8 channels (1138, 1284).”
TRP channels and pain. (2013, background): “Furthermore, mutagenesis experiments suggest that, as in the case of TRPV1, a positively charged putative PIP2-interacting domain resides in the C-terminal cytoplasmic tail of TRPM8, specifically within the Trp domain (Rohács et al. 2005).”