Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

By D. Jia, R. Jurkowska, Xing Zhang, Albert Jeltsch, Xiaodong Cheng. Nature, 2007

820 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/5b1ff63040df9af43dc92e5b18fc5de8fe2e24f4

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In Genetics

In Molecular Biology

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Dynamic CpG island methylation landscape in oocytes and preimplantation embryos (2011, background): “but are not distinct at the sequence level, including in CpG periodicit”
Methylation multiplicity and its clinical values in cancer (2021, neutral): “16).”
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia (2011, background): “We further addressed the possible structure-function relationship of the mutants as the crystal structure of DNMT3A was availabl”
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice (2008, background): “Recent studies have begun to unravel the biochemistry of de novo DNA methylation machinery, showing that DNA methylation might be preceded by specific histone modifications ( Jia et al., 2007; Ooi et al., 2007).”
Repurposing the CRISPR-Cas9 system for targeted DNA methylation (2016, background): “While its external addition is indispensable for significant DNA methylation activity in vitro (29), DNMT3L seems to be efficiently recruited to an active complex by DNMT3A in a living cell (30).”
Establishing, maintaining and modifying DNA methylation patterns in plants and animals (2010, background): “, a model was proposed in which DNMT3L binds unmethylated H3K4 tails and recruits the DNMT3A2 isoform to specific loci, including imprinted loc”
CpG islands – ‘A rough guide’ (2009, background): “This protein associates with, and facilitates the action of the de novo methyltransferases [50–53].”
DNA methylation: a historical perspective. (2022, positive): “Combined with the DNMT structure and biochemistry papers from 2007 [195,196], these studies helped build a consensus that H3K4 methylation may shield these promoters from DNMTs.”
Linking DNA methylation and histone modification: patterns and paradigms (2009, background): “De novo DNA methylation is carried out by the DNA methyltransferase enzymes DNMT3A and DNMT3B complexed with DNMT3”
DNA Methylation and Its Basic Function (2013, background): “Although Dnmt3L has no catalytic function of its own, it associates with the Dnmt3a and Dnmt3b and stimulates their methyltransferase activity (Hata et al, 2002; Suetake et al, 2004; Jia et al, 2007).”
Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “DNMT3L interacts with DNMT3A and influences the structure of the enzyme and its ability to bind and methylate DN”
Epigenetic events in mammalian germ-cell development: reprogramming and beyond (2008, background): “A crystallographic analysis of the complexed C-terminal domains of DNMT3A and DNMT3L revealed a tetrameric structure with two active site”