Environmental epigenomics and disease susceptibility

By R. Jirtle, Michael K. Skinner. Nature reviews genetics, 2007

2,441 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5abb7792b2c37a9f69191ac772cd9559fefa9a01

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Citations in the corpus

Prenatal environmental exposures, epigenetics, and disease (2011, positive): “As elaborated by Jirtle and Skinner [7], in order to consider transgenerational effects on the epigenome to be a plausible mechanism for a disease phenotype, the epigenetic changes and the disease phenotype must be observed in the F3 generation.”
Rapid DNA methylation changes after exposure to traffic particles. (2009, background): “Although changes in DNA methylation have been proposed to mediate the effects of environmental factors on human health (6), relations with environmental exposures and the time-related patterns of such variations are largely unexplored.”
Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. (2009, background): “Scientific evidence increasingly suggests that exposures during the intrauterine period can increase the risk for developing diseases in later life (1, 2).”
DNA methylation profiles in monozygotic and dizygotic twins (2009, background): “DNA methylation shows only partial stability, which could be caused by a wide variety of factors, including developmental programs, environment, hormones and stochastic event”
Endocrine Disrupting Chemicals and Disease Susceptibility (2011, background): “The majority of environmental factors and toxins do not have the ability to alter DNA sequence or promote genetic mutations at normal physiological doses [54-56].”
Health psychology: developing biologically plausible models linking the social world and physical health. (2009, background): “For example, studies in animals indicate that some in utero or early-life exposures, such as exposure to cigarette smoking, vitamin B12, and folic acid, can induce epigenetic alterations that persist through the organism’s lifetime ( Jirtle & Skinner 2007).”
Targets and dynamics of promoter DNA methylation during early mouse development (2010, positive): “Inheritance of epigenetic information has been implicated in non-Mendelian transmission of phenotypes such as the coat color controlled by the Agouti viable yellow allele or defects linked to environmental factor”
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination (2013, background): “The sources of this variation are likely the consequence of genetics, epigenetics, and the history of antigenic exposure (1, 2).”
Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution (2009, positive): “…during pregnancy, direct induction of the embryo’s germ cells has to be excluded; therefore, three generations of transmission (from F0 to F3) are required to establish that epigenetic inheritance, rather than direct induction of the embryo and its germline, has occurred (Jirtle and Skinner 2007).”
Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “Epigenetics describes stable changes in the activity of a gene that arise without changes to its DNA sequence (Jirtle & Skinner, 2007; for a nontechnical background on the how genes work, see Clark & Russell, 2005).”
Non-genetic inheritance and changing environments (2013, background): “This adds a layer of complexity, although it is possible to test for TGP in internal fertilizers with a proper experimental design [21].”
Epigenetics as a unifying principle in the aetiology of complex traits and diseases (2010, background): “Epigenetic solutions There is already fragmentary experimental evidence that epigenetics can account for some of the variation that had previously been attributed to environmental and heritable effect”
Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes (2009, neutral): “Moreover, supplementation of the diets of pregnant mice with methyl donors such as folic acid, vitamin B12, choline, or betaine increases DNA methylation of the gene in the offspring, resulting in low agouti expression and a brown coat color (55).”