Prenatal environmental exposures, epigenetics, and disease
By Frederica Perera, Julie Herbstman. Reproductive Toxicology, 2011
612 citations recorded by the source corpus.
This review summarizes recent evidence that prenatal exposure to diverse environmental chemicals dysregulates the fetal epigenome, with potential consequences for subsequent developmental disorders and disease manifesting in childhood, over the lifecourse, or even transgenerationally. The primordial germ cells, embryo, and fetus are highly susceptible to epigenetic dysregulation by environmental chemicals, which can thereby exert multiple adverse effects. The data reviewed here on environmental contaminants have potential implications for risk assessment although more data are needed on individual susceptibility to epigenetic alterations and their persistence before this information can be used in formal risk assessments. The findings discussed indicate that identification of environmental chemicals that dysregulate the prenatal epigenome should be a priority in health research and disease prevention.
Subfields: Health, Toxicology and Mutagenesis, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/c2ff1945546ffe4418c25e77617fbe1c1116191e
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Citations in the corpus
- A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. (2013, background): “High prenatal exposure to PAHs is also associated with low IQ at age three, increased behavioral problems at ages six to eight, and childhood asthma (Edwards et al., 2010; Perera and Herbstman, 2011).”