DNA methylation profiles in monozygotic and dizygotic twins

By Z. Kaminsky, Thomas Tang, Sun-Chong Wang, Carolyn Ptak, Gabriel Oh, A. Wong, L. Feldcamp, C. Virtanen, J. Halfvarson, C. Tysk and 6 more. Nature Genetics, 2009

700 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5da7c020f5cb7f4775abdf9de30dc3a7ec9ea1bd

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Citations in the corpus

Epigenetics as a unifying principle in the aetiology of complex traits and diseases (2010, background): “Third, DNA methylation profiles are more similar between monozygotic twins than between dizygotic twins, also supporting the idea that zygotic epigenetic signals survive, at least in par”
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population (2012, background): “Regions that exhibit evidence for DNA methylation heritability, such as the IGF2/H19 region, also exhibit more stable DNA methylation levels over time and tend to occur in functionally important promoter regions [4].”
Immunopathogenesis of rheumatoid arthritis (2017, unknown): “Note also that gene sequences are not the sole determinant of heritability, and epigenetic marks probably also contribute, especially for monozygotic twins (Kaminsky et al., 2009).”
Distinct DNA methylomes of newborns and centenarians (2012, background): “Considering that epigenetic regulation has emerged as a critical driver of cell fate and survival that targets many pathways (3, 4), that epigenetic drift can occur even in genetically identical humans (5, 6), and that DNA methylation patterns are disrupted in a wide range of common human diseases (”
The discordant MZ-twin method: One step closer to the holy grail of causality (2009, background): “Differences in methylation, which may themselves be a result of non-shared environmental influences, may produce phenotypic differences between MZ twins (e.g., with respect to psycho-behavioral adjustment; Bruder et al., 2008; Kaminsky et al., 2009).”
Epigenetic modifications and human disease (2010, background): “In multicellular organisms, the ability of epigenetic marks to persist during development and potentially be transmitted to offspring may be necessary for generating the large range of different phenotypes that arise from the same genotyp”
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in Rheumatoid Arthritis (2013, background): “This may be due in part to several limitation to such studies including (1) the cellular heterogeneity of the sample material, and (2) the potential for methylation changes that are a consequence of disease rather than part of the etiology Here, we apply a series of ad hoc filtering steps that addre”
Epigenetics and the environment: emerging patterns and implications (2012, background): “Furthermore, dizygotic twins show more epigenetic differences than monozygotic twin”