FOXP3: of mice and men.

By Steven F. Ziegler. Annual Review of Immunology, 2006

1,019 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5a9611ccb53a657f7e62bef9d59a0ff5763e0799

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Citations in the corpus

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells (2006, background): “Subsequent studies in the mouse showed that FoxP3-defi cient animals lack T reg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression (30).”
Foxp3 in control of the regulatory T cell lineage (2007, background): “In humans, Foxp3 is also highly expressed in CD25 + CD4 + T cells with suppressor functio”
Epigenetic Control of the foxp3 Locus in Regulatory T Cells (2007, unknown): “function, especially in the human system [28,29].”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “It is noteworthy that there are differences in Foxp3 expression upon activation of conventional T cells in humans and mice (Ziegler, 2006).”
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. (2007, background): “…in Foxp3 underlie the devastating lymphoproliferation and multiorgan autoimmunity in Scurfy mutant mice and human patients with the immunodysre- 786 Immunity 27, 786–800, November 2007 ª2007 Elsevier Inc gulation, polyendocrinopathy, and enteropathy, X linked (IPEX) syndrome (Ziegler, 2006).”
FOXP3 controls regulatory T cell function through cooperation with NFAT. (2006, unknown): “A mutation in the DNA binding domain of FOXP2 cosegregates with a congenital speech disorder (Lai et al., 2001), whereas mutations in FOXP3 are linked to autoimmune disease (Ziegler, 2006).”
CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation (2007, background): “The N-terminal domain of FoxP3 is unique to the FOXP subfamily, and it is critical for transcriptional repression (3).”
Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders (2010, background): “It is a regulator of T-cell tolerance and is necessary for the development and function of Tregs (7).”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “While the functions of Foxp3 are clearly shared between humans and mice, there are some apparent differences in the control of FOXP3 expression in activated human T cells (187).”
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “biological roles may not be equivalent (67, 68).”