The Biochemistry of n-3 Polyunsaturated Fatty Acids* 210

By D. Jump. Journal of Biological Chemistry, 2002

660 citations recorded by the source corpus.

have effectson diverse physiological processes impacting normal health andchronic disease, such as the regulation of plasma lipid levels (1–4),cardiovascular (5–7) and immune function (8), insulin action (9,10), and neuronal development and visual function (11) (see TableI, supplemental material). Ingestion of

Subfields: Biochemistry, Surgery

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In Biochemistry

1. D. Tocher
2. J. Bell
3. Magnus Ingelman-Sundberg
4. G. Barceló-Coblijn
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Citations in the corpus

• The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. (2010, background): “acids then serve as precursors for the synthesis of longer PUFAs, including the arachidonic (C20:4n 6) and docosahexaenoic acids (C22:6n 3) required for various physiological functions [123,124].”
• Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. (2004, background): “The first transcription factor that was identified as being regulated by fatty acids was the peroxisome proliferator-activated receptor- (PPAR ) (77), a member of the PPAR family, which also comprises PPAR (also referred to as PPAR ) and PPAR (3 isoforms: 1, 2, and 3).”
• Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish (2003, background): “Much work has gone into elucidating these mechanisms, and, in particular, PUFA are now known to directly influence the activities of a variety of transcription factors that have in turn been shown to be critical regulators of a growing list of genes involved in lipid homeostatic processes (Jump, 200”
• Effects of diets containing vegetable oil on expression of genes involved in highly unsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar) (2004, background): “Specifically, PUFA are known to bind and directly influence the activities of a variety of transcription factors including members of the nuclear hormone receptor family, peroxisome proliferator activated receptors (PPARs), which in turn have been shown to be regulators of many genes involved in lip”
• Effects of diets containing linseed oil on fatty acid desaturation and oxidation in hepatocytes and intestinal enterocytes in Atlantic salmon (Salmo salar) (2002, background): “…by a number of direct and indirect mechanisms (Jump et al. 1999) and are known to bind and directly influence the activities of a variety of transcription factors including PPARs, which in turn have been shown to be regulators of many genes involved in lipid homeostatic processes (Jump 2002).”
• Effect of nutrition on fatty acid profiles of riverine, lacustrine, and aquaculture-raised salmonids of pre-alpine habitats (2010, background): “In particular, polyunsaturated fatty acids (PUFA) are integral constituents of cell membranes and enhance membrane permeability (Jump, 2002).”
• Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. (2009, background): “act role of DHA is unknown, it modulates important membrane functions such as ion or solute transport, receptor activity, and adenylate cyclase activity [77,144–147].”