The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.
By H. Guillou, D. Zadravec, Pascal G. P. Martin, A. Jacobsson. Progress in lipid research, 2010
823 citations recorded by the source corpus.
Subfields: Biochemistry, Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/298ff97ebd537e7a1f1779f698bcf18c6fb69885
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In Biochemistry
In Endocrinology, Diabetes and Metabolism
In Nutrition and Dietetics
Citations in the corpus
- Elongation of long-chain fatty acids in rabbitfish Siganus canaliculatus: Cloning, functional characterisation and tissue distribution of Elovl5- and Elovl4-like elongases (2012, background): “In addition to 18:4n-3 and 18:3n-6, assayed in the present study, other potential C18 PUFA substrates for Elovl5 could include 18:3n-3 and 18:2n-6 (Guillou et al., 2010).”
- Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. (2011, background): “For example, insulin is known to increase the hepatic expression of various fatty acid desaturases, including SCD1, D5D, and D6D (24–27), in animals.”
- Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids (2013, background): “Palmitate, in turn, is a substrate for various elongation and desaturation reactions to accommodate a cell’s need for a diversity of fatty acids, of which the most abundant is the monounsaturated fatty acid oleate (C18:1) (12).”