Altered macrophage differentiation and immune dysfunction in tumor development.

By A. Sica, V. Bronte. Journal of Clinical Investigation, 2007

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View Paper: https://www.semanticscholar.org/paper/594b95553f295232249029ef1fe613c9027ee0c4

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Citations in the corpus

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB (2009, background): “Accumulation of p50 homodimers has been observed in endotoxin-tolerant macrophages (10), as well as in tumor-associated macrophages (11, 12), suggesting an important role in the modulation of immune and inflammatory functions in infection and cancer.”
Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “M-CSF, IL-6 and VEGF are other molecules able to influence MDSC activities significantly and IL-10, in particular, sustains the suppressive phenotype [33, 34].”
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. (2010, background): “We identified the two major MDSC subsets: CD11b+Gr-1hiCD62L+F4/80+/ granulocytic and CD11b+Gr-1lo CD62L F4/80+ monocytic cells, as previously described (Gabrilovich and Nagaraj, 2009; Sica and Bronte, 2007; Youn et al., 2008).”
Myeloid-derived suppressor cell heterogeneity and subset definition. (2010, background): “suppressive potential both as immature precursors and mature cells [13,25 ], as previously shown [3,26].”
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives (2008, background): “Initial explanations included the development of ‘blocking antibodies’ (5), the production of suppressor factors by tumor cells (6, 7), and the generation of suppressor macrophages and dendritic cells (DCs) (8).”
Role of macrophage targeting in the antitumor activity of trabectedin. (2013, background): “Purified CD11b+ Ly6Gneg Ly6Chigh MDSC significantly inhibit the proliferation of splenocytes from OT-1 mice stimulated with ovalbumin.”
The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “While emphasis has been on the protumor functions of TAMs and on the related myeloid-derived suppressor cells (9), classically fully activated macrophages (M1) can exert cytotoxic activity on tumor cells and elicit tumor-destructive reactions centered on the vessel wall.”
The tumor microenvironment at a glance (2012, background): “Myeloid-derived suppressor cells (MDSCs) are currently defined as a population of inhibitory immune cells that are increased in numbers in a variety of mouse and human cancers (Gabrilovich et al., 2012; Sica and Bronte, 2007).”
Coordinated regulation of myeloid cells by tumours (2012, background): “This subset of MDSCs may also include progenitors that give rise to a subset of CD11b hi GR1 low LY6G − F4/80 hi MHC-II + macrophages with potent immunosuppressive propertie”