Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis

By A. Al‐Mehdi, K. Tozawa, A. Fisher, L. Shientag, A. Lee, Ruth J. Muschel. Nature Medicine, 2000

735 citations recorded by the source corpus.

Subfields: Biotechnology, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/5807df8d8958cbe6e4f2ef792f06a3c370e883fe

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Citations in the corpus

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation (2014, background): “In vivo and ex vivo studies have been performed to investigate cancer cell extravasation in mouse models through liver sinusoids and pulmonary circulation (10) or in zebrafish embryos (11).”
Cancer metastasis: building a framework. (2006, background): “In some cases, considerable growth within the intravascular space may occur until the lesion physically bursts through the limiting surrounding vasculature (Al-Mehdi et al., 2000).”
Circulating tumor cells: approaches to isolation and characterization (2011, positive): “Intravascular aggregation of cancer cells with apparent attachment to the endothelium has been described after injection of breast and prostate cancer cells as well as fibrosarcoma cells (Al-Mehdi et al., 2000; Glinsky et al., 2003).”
A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth (2009, methodology): “Thus to explore the role of the macrophages in metastatic seeding and extravasation mechanistically, we used an intact ex-vivo lung imaging system that preserves the physiological lung structure [42].”
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. (2006, neutral): “proceeded to multiply within the vasculature (86).”
Circulating tumor cells (CTC) detection: clinical impact and future directions. (2007, background): “Actually, it has been shown that CTM may give rise to metastasis without extravasation, by attaching to vessel walls of arterioles and capillaries, and proceeding to cell proliferation within the vasculature, rupture of capillary walls and formation of microor macro metastases [16] (Fig.”
Matrix metalloproteinases and tumor metastasis (2006, background): “Similarly, metastatic tumor cells arrested in pulmonary arterioles and capillaries were observed growing entirely within the blood vessels [178].”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, background): “Extravasation Once lodged in the microvasculature of distant organs, CTCs may initiate intraluminal growth and form a microcolony that eventually ruptures the walls of surrounding vessels, thereby placing tumor cells in direct contact with the tissue parenchyma (Al-Mehdi et al., 2000).”
The seed and soil hypothesis revisited - the role of tumor-stroma interactions in metastasis to different organs (2011, background): “occurs when the vessel becomes ruptured by the expanding mass.(7) Recent studies suggest that a distinct population of CD11bþ macrophages may recognize emigrating tumor cells and assist them with the invasion process.”