Circulating tumor cells (CTC) detection: clinical impact and future directions.

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Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer (2009, background): “To date, a variety of research methods have been developed to isolate and enumerate CTC [8].”
Detection, clinical relevance and specific biological properties of disseminating tumour cells (2008, methodology): “Enrichment is usually based on density-gradient centrifugation and immunomagnetic procedure”
Circulating tumor cells: approaches to isolation and characterization (2011, neutral): “However, significant challenges include the frequency of both falsepositive and false-negative PCR results and the difficulty in quantitating relative levels of expression without prepurification of these extraordinarily rare cells (Paterlini-Brechot and Benali, 2007; Pantel et al., 2008).”