Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

By Justin L. Sonnenburg, Jian Xu, Douglas D. Leip, Chien-Huan Chen, Benjamin P. Westover, J. Weatherford, Jeremy D. Buhler, Jeffrey I. Gordon. Science, 2005

1,176 citations recorded by the source corpus.

Subfields: Ecology, Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5770f825e573c00badca438062410bc63cf95bdc

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Citations in the corpus

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 (2008, methodology): “thetaiotaomicron strain VPI-5482 [harvested from overnight culture in TYG medium (6)], and M.”
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation. (2017, background): “Previous studies onmucus utilization byB. thetaiotaomicron and A. muciniphila have suggested that mucus utilization is reserved for a subset of the intestinal microbiota (Derrien et al., 2004; Sonnenburg et al., 2005; Tailford et al., 2015a).”
Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts (2011, background): “When these dietary substrates are withheld, as in mice fed a simple sugar diet [20] or in neonatal mice suckling on mother’s milk [21], expression of the ‘‘pectin PULs’’ is reduced.”
Effects of Gut Microbes on Nutrient Absorption and Energy Regulation (2012, background): “Microbes in the large intestine allow the host to salvage energy from otherwise indigestible carbohydrates and proteins by providing a variety of enzymes required for their metabolism.(62,63) For example, Bacteroides thetaiotaomicron (B theta), a prominent commensal gut microbe, produces 226 predict”
The human gut microbiome: ecology and recent evolutionary changes. (2011, background): “Other traits enable persistence in the gut, such as the ability to degrade sialic acid via N-acetylneuraminic lyases (2), and other components of host mucins, when preferred dietary substrates are depleted (85).”
Immune adaptations that maintain homeostasis with the intestinal microbiota (2010, background): “A primary function of intestinal bacteria is to enhance host digestive efficiency by degrading dietary polysaccharide”
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. (2014, positive): “Mucosally adherent bacteria reside primarily within the outer intestinal mucus layer(39) where many of the bacterial taxa are saccharolytic (ie, capable of harvesting energy through the digestion of carbohydrates).(2,40) To compare mucus-associated gut microbiota relative to the stool, we collected ”