Induction of neurogenesis in the neocortex of adult mice

By Sanjay S. P. Magavi, B. Leavitt, J. D. Macklis. Nature, 2000

1,249 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/5715820f0f33acb097bc7446b6f69064e1646a51

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

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Citations in the corpus

Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus (2001, background): “Furthermore, Magavi et al. (2000) demonstrated that newly generated neurons can be observed in the adult mouse cerebral cortex after lesion of layer VI neurons.”
Adult generation of glutamatergic olfactory bulb interneurons (2009, background): “On the other hand, it has been suggested that apoptotic cell death in the cerebral cortex elicits the migration of neuroblasts from the SEZ with the ability to replace glutamatergic projection neuron”
Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells (2001, background): “, 1999), it was only apparent in the adult rodent cerebral cortex after a discrete lesion (Magavi et al., 2000).”
Neurogenesis in Adult Subventricular Zone (2002, background): “NC, Neocortex; cc, corpus callosum. neocortex has also been suggested (Gould et al., 1996; Magavi et al., 2000), but this migration has not been demonstrated.”
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. (2007, background): “…whether there was a difference in the population of transient migrating neuroblasts or immature neurons, we quantified the number of cells stained with doublecortin (DCX), a microtubule associated protein (Brown et al., 2003; Francis et al., 2002; Gleeson et al., 1999; Magavi et al., 2000).”
Rat forebrain neurogenesis and striatal neuron replacement after focal stroke (2002, background): “Recent studies of focally induced apoptosis in adult mouse neocortex indicate that some newly generated neurons in the adult are able to survive for prolonged periods and send appropriate long-distance projections.(42) Therefore, integration of new neurons into mature networks after brain injury is ”
Astroglia induce neurogenesis from adult neural stem cells (2002, background): “Outside these two regions, proliferating cells give rise to new glia but not to neurons in the intact adult CN”
Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, positive): “Currently only one group has reported the regeneration of complex long-tract projection neurons following a highly selective and nontraumatic elimination of cortical projection neurons (Magavi et al., 2000).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “In contrast, other recent reports, analysed with more rigorous methods as noted earlier, are unable to reproduce these findings, and report a complete absence of constitutive cortical neurogenesis in both rodents and primates (Magavi et al. 2000; Kornack & Rakic 2001; Ehninger & Kempermann 2003; Kok”
Neuronal subtype specification in the cerebral cortex (2007, methodology): “In support of this idea, previous experiments have shown that with the appropriate stimuli, progenitors in the adult mouse neocortex can be induced to generate new projection neuron”