Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

By J. Parent, Z. Vexler, Chao Gong, N. Derugin, D. Ferriero. Annals of Neurology, 2002

1,079 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/b0ca103d3e3f8b4900c22e7631404a0077b1a69b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. D. C. Lie
5. D. Abrous
6. M. Koehl
7. Z. Kokaia
8. O. Lindvall

In Developmental Neuroscience

1. Hongjun Song
2. Fred H. Gage
3. Guo-li Ming
4. D. Abrous
5. D. C. Lie
6. M. Le Moal
7. M. Koehl
8. Z. Kokaia

In Neurology

1. Hongjun Song
2. Fred H. Gage
3. Guo-li Ming
4. D. Abrous
5. S. Carmichael
6. Z. Kokaia
7. D. C. Lie
8. M. Le Moal

Citations in the corpus

• Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum (2006, background): “SVZ cells generate mature neurons in the striatum Previous reports have described BrdU-labeled newborn cells as expressing markers for mature neurons within the damaged striatum as early as 30 d after the induction of ischemia (Arvidsson et al., 2002; Parent et al., 2002).”
• Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke (2006, background): “After maturation, a substantial portion of the new neurons express markers characteristic of those mature neurons that have died, that is, striatal projection neurons [4, 5 ]. However, this potential self-repair mechanism is thought to operate only acutely after stroke, with the number of generated”
• The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “In addition, neuroblasts migrate laterally (diverted from the RMS) toward the injured striatum and cortex as an attempt to replace neurons lost following focal ischemia [4, 88 , 141].”
• Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “These findings suggest the possibility that new neurons from the SVZ are attracted by lesion-derived migratory cues.”
• Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Other groups have reported similar and complementary results in hippocampus (Nakatomi et al. 2002) and striatum (Arvidsson et al. 2002; Parent et al. 2002b), confirming and further supporting this direction of research.”
• Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “, 2014), suggesting that the mature brain is capable of replacing neurons lost after ischemic injury (Parent et al., 2002).”
• Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species (2013, background): “…injury to the adult brain, increased neurogenesis is typically stimulated in the SVZ and SGZ, with a proportion of newborn neurons migrating towards the injury site (Parent et al., 2002; Richardson et al., 2007; Urrea et al., 2007) (also see (Kernie and Parent, 2010) for a concise review).”
• A Neurovascular Niche for Neurogenesis after Stroke (2006, background): “…express phenotypic markers of mature neurons, including neuronalspecific nuclear protein (NeuN), and region-specific mature neuronal markers, such as calbindin and dopamine and cAMPregulated phosphoprotein-32 (Arvidsson et al., 2002; Parent et al., 2002), and form synapses (Yamashita et al., 2006).”
• Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy (2006, background): “The expression patterns of these markers previously allowed us to identify ectopic neuroblast migration in the forebrain SVZolfactory bulb pathway after seizure- or stroke-induced injury.(17,31) We therefore performed immunohistochemistry for DCx, TUC-4, and PSA-NCAM to determine whether neuroblasts”
• Adult neurogenesis: from precursors to network and physiology. (2005, background): “2% of the cell loss) and assume the phenotype of cells lost due to the lesion (24, 239, 429).”
• Stem cell therapy for human neurodegenerative disorders–how to make it work (2004, background): “Stroke leads to increased generation of neurons from NSCs in the subventricular zone (SVZ”