NAD+ metabolism in health and disease.

By Peter Belenky, Katrina L. Bogan, Charles Brenner. 2007

957 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Oncology, Physiology

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Citations in the corpus

ECOD: An Evolutionary Classification of Protein Domains (2014, background): “Thus, SAM and NAD(P) share the adenosine part but differ in the other half, and the two enzyme superfamilies exploit the dissimilar parts of the cofactors to catalyze different reactions [41,42,43].”
NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, neutral): “Increasing evidence has suggested that the pyridine nucleotides NAD and NADP have far more extensive biological functions than their classical functions (27, 29, 233, 328, 329).”
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches (2019, background): “In the opposite direction, lactate is oxidized to form pyruvate, while NAD+ is reduced to NADH (63).”
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “In the pancreas, SIRT1 regulates insulin secretion by decreasing uncoupling protein-2 expression and mitochondrial uncoupling, allowing a more efficient ATP synthesis (109, 110).”
NAD+ intermediates: The biology and therapeutic potential of NMN and NR (2017, neutral): “2 Cell Metabolism 27, February 6, 2018 Reflecting such rapid progress in the field, there have already been a number of excellent review articles about general NAD biology and its relevance to disease (Belenky et al., 2007; Canto et al., 2015; Chini et al., 2016; Fang et al., 2017; Imai and Guarente”
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. (2007, background): “In prokaryotes and lower eukaryotes, such as yeast, NAD is synthesized by the de novo pathway via quinolinic acid and by the salvage pathway via nicotinic acid (Belenky et al., 2007; Revollo et al., 2007; Rongvaux et al., 2003) (see Figure S1A in the Supplemental Data available with this article onl”
Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes (2015, background): “…phosphorylated derivatives (NADH, NADP, and NADPH) have many functions in cells, such as serving as hydride donors and acceptors in redox reactions (Belenky et al., 2007; Houtkooper et al., 2010), participation in bacterial and DNA ligase reactions (Wilkinson et al., 2001), and roles as molecules…”