The molecular basis of water transport in the brain

By M. Amiry-Moghaddam, Ole Petter Ottersen. Nature Reviews Neuroscience, 2003

738 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/55bf5b8e65fd2cf1683bebf1cd2155cc07a45311

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Embodiment or envatment? Reflections on the bodily basis of consciousness (2010, background): “…to neuronal function as electrolyte balance (Hebert, Brown, and Harris 1997; Simard and Nedergaard 2004; Yano, Brown, and Chattopadhyay 2004) and water homeostasis (Amiry-Moghaddam and Ottersen 2003; Grubb, Raichle, and Eichling 1977), can be seen by reviewing any standard physiology textbook.”
Modeling dendrite density from magnetic resonance diffusion measurements (2007, background): “The predominant CNS aquaporin family, aquaporin-4, has recently been found to be almost exclusively expressed in astrocytes (Amiry-Moghaddam and Ottersen, 2003).”
Cation-chloride cotransporters and neuronal function. (2009, background): “Interestingly, neurons are thought to be devoid of water channels (aquaporins; Amiry-Moghaddam and Ottersen, 2003), which lowers their sensitivity to osmotic challenges.”
Physiological roles of aquaporin-4 in brain. (2013, background): “It is now well documented that the entire DAPC is held in place through its attachment to laminin, a principal component of the pericapillary basal lamina (5, 49, 116, 131, 200).”
Diffusion in Brain Extracellular Space (2008, positive): “The increased volume fraction of the immature ECS is therefore expected to attenuate the concentration of released neuroactive substances, especially K and glutamate (358, 393), and might actually increase the threshold, as has been postulated for aquaporin-4 knockout mice (9, 38).”
From structure to disease: the evolving tale of aquaporin biology (2004, background): “Aquaporins are expressed in glial cells at sites that are indicative of a role for them in water homeostasis in the brai”
Physiology of Astroglia. (2018, neutral): “1 channels links K and water movements (35).”
Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. (2006, background): “Immunohistochemical studies show intense AQP4 immunoreactivity in the astrocytic end feet that abut capillaries and pia in the brain and spinal cord, the glial lamellae of the supraoptic nucleus in the hypothalamus, and the basolateral membranes of ependymal cells.(4,7) Consistent with its location ”
Impairment of paravascular clearance pathways in the aging brain (2014, background): “Along these processes, as much as 50% of the vessel-facing membrane is populated by crystalline plaques (termed orthogonal arrays of particles) of AQP4 water channels.(24) We have previously demonstrated that perivascular AQP4 facilitates paravascular CSF–ISF exchange,(14) and have proposed that the”
Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. (2007, background): “…and pia in the brain and spinal cord, particularly in the subpial and subependymal zones, as well as in the glial lamellae of the supraoptic nucleus in the hypothalamus (Jung et al., 1994; Frigeri et al., 1995; Nielsen et al., 1997; Venero et al., 1999; Amiry-Moghaddam and Ottersen, 2003).”