Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression.

By S. Pittock, B. Weinshenker, C. Lucchinetti, D. Wingerchuk, J. Corboy, V. Lennon. Archives of Neurology, 2006

711 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Computer Networks and Communications, Software

View Paper: https://www.semanticscholar.org/paper/48899e59bbafb252b0a6f96829d48a13eaa18a24

How researchers see this paper

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Hans Lassmann
S. Roemer
Toshiyuki Takahashi
Wolfgang Brück
C. Lucchinetti
Joseph E. Parisi
S. Jarius
K. Fujihara

Citations in the corpus

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome (2016, background): “5 months since onset, median 52 [1-507] months), the disease took a relapsing course in most cases.”
Physiological roles of aquaporin-4 in brain. (2013, neutral): “There is an extensive literature on the role of AQP4 in neuromyelitis optica (NMO) (25, 26, 62, 70, 84, 106, 145, 146, 152, 153, 160).”
Differential diagnosis of suspected multiple sclerosis: a consensus approach (2008, neutral): “medulla, and other brainstem areas [41,42].”
Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. (2007, background): “Recent MRI studies have established conclusively that lesions in NMO may target the brain, even relatively early in the course of the disease, and that certain brain lesions are far more common in NMO than in MS (Pittock et al., 2006a,b).”
Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients (2012, background): “Accordingly, brainstem lesions as detected by MRI were not in all cases restricted to the medulla oblongata and to the diencephalon, which are known sites of predilection in NMO [59], but may also occur in the pons, the cerebral peduncles, and the cerebellar peduncles.”
The Immunopathology of Multiple Sclerosis: An Overview (2007, background): “However, more recently it became clear that relapsing variants of Devic’s neuromyelitis optica are in fact more common, and lesions may extend beyond the spinal cord and the optic systems (72, 92, 93).”
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. (2007, background): “Consistent with the distribution of AQP4, the brain lesions of NMO were reported to be localized in the periventricular and periaqueductal areas (Misu et al., 2005a; Nakashima et al., 2006; Pittock et al., 2006a, b), and myelitis in NMO often involves the central gray matter.”