Impairment of paravascular clearance pathways in the aging brain

By Benjamin T. Kress, Jeffrey J. Iliff, Maosheng Xia, Minghuan Wang, Helen S. Wei, Douglas M. Zeppenfeld, Lulu Xie, Hongyi Kang, Qiwu Xu, Jason Liew and 4 more. Annals of Neurology, 2014

1,357 citations recorded by the source corpus.

In the brain, protein waste removal is partly performed by paravascular pathways that facilitate convective exchange of water and soluble contents between cerebrospinal fluid (CSF) and interstitial fluid (ISF). Several lines of evidence suggest that bulk flow drainage via the glymphatic system is driven by cerebrovascular pulsation, and is dependent on astroglial water channels that line paravascular CSF pathways. The objective of this study was to evaluate whether the efficiency of CSF–ISF exchange and interstitial solute clearance is impaired in the aging brain.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/569d2011384c0ea2f23fb59f7e716a5e068889e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Maiken Nedergaard
2. S. Vatnehol
3. Geir Ringstad
4. P. Eide
5. Jeffrey J. Iliff
6. R. Deane
7. W. Klein
8. K. Viola

In Neurology

1. Maiken Nedergaard
2. S. Vatnehol
3. Geir Ringstad
4. P. Eide
5. R. Deane
6. Itender Singh
7. C. Iadecola
8. M. Sofroniew

Citations in the corpus

• Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury (2014, background): “These changes within perivascular domains are associated with the impairment of interstitial amyloidclearance (Zlokovic, 2005; Kress et al., 2014), suggesting that disruption of perivascular cellular function may render the aging brain vulnerable to misaggregation of amyloid- and other proteins, and”
• Physiology of Astroglia. (2018, neutral): “Glymphatic transport declines significantly as a function of aging and more rapidly in rodent models of Alzheimer’s disease, stroke, and diabetes (542, 793, 904, 1365).”
• The Glymphatic System – A Beginner's Guide (2015, neutral): “AQP4 is no longer confined to astrocytic endfeet but present in astrocytes parenchymal processes [85] (Fig.”
• Mechanisms of Vascular Aging (2018, background): “between age-related glymphatic dysfunction and amyloid pathologies.(248) These areas are attractive targets for future”
• Glymphatic MRI in idiopathic normal pressure hydrocephalus (2017, background): “It can therefore not be established to what degree iNPH disease or age/gender contributed to differences between groups, while reduced glymphatic function should be expected with normal ageing (Kress et al., 2014).”
• The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade (2018, background): “Recent studies in mice show that glymphatic activity decreases sharply during aging, resulting in decreased A clearance from the brain [320].”