Cation-chloride cotransporters and neuronal function.

By P. Blaesse, M. S. Airaksinen, C. Rivera, Kai Kaila. Neuron, 2009

818 citations recorded by the source corpus.

Recent years have witnessed a steep increase in studies on the diverse roles of neuronal cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription, posttranslational modification, and trafficking are on par with what is known about ion channels. The cell-specific and subcellular expression patterns of different CCC isoforms have a key role in modifying a neuron's electrophysiological phenotype during development, synaptic plasticity, and disease. While having a major role in controlling responses mediated by GABA(A) and glycine receptors, CCCs also show close interactions with glutamatergic signaling. A cross-talk among CCCs and trophic factors is important in short-term and long-term modification of neuronal properties. CCCs appear to be multifunctional proteins that are also involved in shaping neuronal structure at various stages of development, from stem cells to synaptogenesis. The rapidly expanding work on CCCs promotes our understanding of fundamental mechanisms that control brain development and functions under normal and pathophysiological conditions.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/36cd6f58806c02b884e77c0572701c547589e369

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Citations in the corpus

Mechanisms underlying spontaneous patterned activity in developing neural circuits (2009, background): “In the spinal cord, hippocampus, neocortex and cerebellum, the cells that will become inhibitory interneurons in adulthood are a primary source of depolarization during developmen”
Inhibitory synaptic plasticity: spike timing-dependence and putative network function (2013, background): “They showed that so long as the veto by post-synaptic action potentials was incorporated, iLTP would strongly increase the selectivity to the overlapping stimulus-pairs, so as to enable accurate decision-making behavior in exclusive-OR (XOR) tasks (Bourjaily and Miller, 2011).”
How Inhibition Shapes Cortical Activity (2011, neutral): “Membrane pumps, by setting intracellular Cl À concentration , play a critical role in regulating the reversal potential of GABA A receptor-mediated currents (Blaesse et al., 2009).”
Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo‐ocular learning (2012, neutral): “The change from perinatal depolarizing GABA response to the hyperpolarizing response in the adult CNS (the ‘GABA switch’) (Cherubini et al , 1991; Ben-Ari et al , 1997) is correlated with a down-regulation of Nkcc1 and an upregulation of Kcc2 (Rivera et al , 1999; Hu¨bner et al , 2001a,b; Stein et a”