Longevity: Extending the lifespan of long-lived mice

By A. Bartke, J. C. Wright, J. Mattison, D. Ingram, Richard A. Miller, G. Roth. Nature, 2001

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How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “…authors propose that impaired insulin/IGF-1/GH signaling extends life span independently of pathways activated by CR (Lakowski and Hekimi, 1998; Bartke et al., 2001; Houthoofd et al., 2003; Min et al., 2008; Bonkowski et al., 2009), others have suggested that impaired insulin/IGF-1 signaling…”
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (2008, background): “This conclusion is supported by the finding that dwarfism and CR may impact lifespan through independent mechanisms [19], and the finding that GH deficiency and CR display minimal overlap at the gene expression level [20].”
Metformin as a Tool to Target Aging (2016, neutral): “There is overwhelming evidence that single gene mutations in nutrientsensing pathways, such as insulin/insulin-like growth factor (IGF) signaling (Bartke et al., 2001) or the mechanistic target of rapamycin (mTOR) signaling pathways, extend lifespan and health span in invertebrates.”
Calorie restriction--the SIR2 connection. (2005, background): “The long-lived dwarf mice, which are missing the growth hormone-IGF-1 axis and other pituitary hormones due to mutation in the pit-1 gene (Brown-Borg et al., 1996), enjoy a robust further extension in their life span on a low-calorie diet (Bartke et al., 2001).”