Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

By D. Munn, Madhav Sharma, J. Lee, K. Jhaver, Theodore S. Johnson, D. Keskin, B. Marshall, P. Chandler, S. Antonia, R. Burgess and 2 more. Science, 2002

1,089 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Immunology

View Paper: https://www.semanticscholar.org/paper/54671198168a501be6a29bf33ce7dae8205ab338

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. D. Munn
2. A. Mellor
3. W. Zou
4. Erika L. Pearce

In Immunology

1. D. Munn
2. A. Mellor
3. W. Zou
4. Lieping Chen
5. J. Wolchok
6. James P. Allison
7. D. Gabrilovich
8. Michael D. Buck

Citations in the corpus

• Immune evasion in cancer: Mechanistic basis and therapeutic strategies. (2015, neutral): “[31] Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, et al.”
• Inhibitory B7-family molecules in the tumour microenvironment (2008, background): “In addition, IFNγ has been shown to stimulate the expression of indoleamine 2,3-dioxygenase (IDO”
• T cell metabolism drives immunity (2015, background): “IDO, which is often expressed at high levels by APCs or tumor cells, can deplete tryptophan within a tissue microenvironment, and this in turn can lead to inhibition of effector T cell proliferation and induction of anergy (Munn et al., 2002; Uyttenhove et al., 2003).”
• Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. (2019, background): “2C), which catalyzes tryptophan depletion and kynurenine production, both of which inhibit T-cell proliferation and cytotoxicity (37).”
• Ido expression by dendritic cells: tolerance and tryptophan catabolism (2004, background): “Subsequent human studies have focused on the more physiologically relevant monocyte-derived DC”
• Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. (2004, methodology): “All MLRs were performed in V-bottom culture wells (Nalge Nunc International, Rochester, New York, USA), as previously described (20), in order to ensure the close cell-cell contact required for optimal sensitivity to IDO-mediated suppression.”
• Modulation of tryptophan catabolism by regulatory T cells (2003, background): “Because IL-10 is known to contribute to stable IDO expressio”
• Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4 (2013, background): “After loading, DCs were purified by Ficoll gradient.”