The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

By M. van de Wetering, E. Sancho, C. Verweij, W. de Lau, I. Oving, A. Hurlstone, K. van der Horn, E. Batlle, D. Coudreuse, Anna-Pavlina G. Haramis and 8 more. Cell, 2002

1,063 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5410d5db9887e1c8689a142f4543002e5ffefcba

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Citations in the corpus

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment (2010, unknown): “APC mutations generally result in a defective β-catenin degradation complex and, as a consequence, the accumulation of β-catenin in the nucleus and the perpetual transcription of Wnt target gene”
Wnt signalling induces maturation of Paneth cells in intestinal crypts (2005, unknown): “We have recently determined the TCF4 target gene programme in colorectal cancer cells and have found that it is physiologically expressed in the proliferative crypt progenitors of the intestinal epitheliu”
Organizing cell renewal in the intestine: stem cells, signals and combinatorial control (2006, unknown): “In the gut, Wnt signalling switches on expression of EphB2 and EphB3 and inhibits expression of ephrin B1 (Ref”
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. (2013, background): “This triggers expansion and transformation of the stem cell compartment and leads subsequently to the development of adenomatous polyps (van de Wetering et al., 2002).”
Normal stem cells and cancer stem cells: the niche matters. (2006, background): “signaling is widely seen in the proliferating crypt cells (37, 38).”
The intestinal crypt, a prototype stem cell compartment. (2013, background): “The first microarray experiment on Wnt-pathway-controlled genes in a human colon cell line unveiled a genetic program shared between colon cancers and crypts (van de Wetering et al., 2002).”
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, unknown): “The CDK inhibitor p21CIP, which is repressed by c-Myc, controls HSC proliferation, and is furthermore required for maintenance of long-term self-renewal (Cheng et al. 2000; van de Wetering et al. 2002).”
The intestinal stem cell. (2008, unknown): “Although the overwhelming majority of the genes were expressed throughout the proliferative crypt compartment (van de Wetering et al. 2002; Van der Flier et al. 2007) or in mature Paneth cells (van Es et al. 2005), we detected several Wnt target genes with a much more restricted expression within…”