Wnt signalling induces maturation of Paneth cells in intestinal crypts

By J. V. Es, P. Jay, A. Gregorieff, M. E. Gijn, Suzanne M. Jonkheer, P. Hatzis, A. Thiele, M. V. D. Born, H. Begthel, Thomas Brabletz and 2 more. Nature Cell Biology, 2005

683 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a7c50ef8b0e61c8db6228df01d6c4ed260988dc2

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Citations in the corpus

Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “In particular, we and others find that the expression of Paneth cell markers, such as antimicrobial peptides (i.e., cryptdins and defensins), are directly stimulated by -catenin/Tcf (Andreu et al. 2005; van Es et al. 2005).”
The intestinal crypt, a prototype stem cell compartment. (2013, background): “Indeed, Hes1 is expressed in most proliferative crypt cells, whereas Math1 is only seen in secretory cells; inhibition of Notch signaling rapidly leads to loss of Hes1 expression and to the consequent induction of Math1 expression in all crypt cells (van Es et al., 2005b).”
Epithelial stem cells: turning over new leaves. (2007, neutral): “Notably, hair keratin genes are transcriptionally regulated by Lef1/ β-catenin (Merrill et al., 2001) and expression of genes specific to Paneth cells, such as cryptidin/defensins, is lost upon deletion of Tcf4 or Wnt receptor Frizzled 5 (van Es et al., 2005a).”
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. (2009, background): “Because of the intimate connection between Wnt signaling and intestinal biology, we have attempted to unravel the TCF4 target gene program activated by this pathway in crypts and colorectal tumors (van de Wetering et al., 2002; van Es et al., 2005; van der Flier et al., 2007).”