Regulatory T cells mediate maternal tolerance to the fetus

By V. Aluvihare, M. Kallikourdis, A. G. Betz. Nature Immunology, 2004

1,666 citations recorded by the source corpus.

Subfields: Immunology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/53c61917146e4ffce900c6576ff2c45d2c769c33

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Munn
2. A. Mellor
3. A. Moffett
4. Shimon Sakaguchi
5. C. Loke
6. W. Zou
7. Alexander Y. Rudensky
8. George Coukos

In Public Health, Environmental and Occupational Health

1. A. Moffett
2. Shimon Sakaguchi
3. C. Loke

Citations in the corpus

• Immunology of placentation in eutherian mammals (2006, background): “Paradoxically, the 'normal' controls used in many of these models are syngeneic pregnancies, clearly something of an oxymoron when thinking of normal human pregnanc”
• Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self (2005, background): “These in vivo and in vitro ways of inducing immunological tolerance to organ transplants could in principle be applied to re-establish self-tolerance in autoimmune disease, control aberrant or excessive immune responses to non-self antigens (immunopathology and allergy) and maintain feto-materna”
• Inflammation and pregnancy: the role of the immune system at the implantation site (2011, background): “(1) Recruitment: Trophoblast sends signals to recruit immune cells towards the implantation site; (2) education: trophoblast influence the differentiation of immune cells; and (3) response: factors produced by trophoblast-educated immune cells support placental formation and function.”
• Ido expression by dendritic cells: tolerance and tryptophan catabolism (2004, background): “From this perspective, it might be relevant that maternal T Reg cells have recently been shown to be required for the maintenance of tolerance to the allogeneic fetu”
• Evolution of the immune system in humans from infancy to old age (2015, neutral): “These include expression only of non-polymorphic non-classical HLA antigens on the trophoblast [71], local immune suppression mediated by infiltrating NK cells [72], monocytes and T regulatory cells [69,73], and inhibition of T-cell activation by tryptophan catabolism [74].”