Inflammation and pregnancy: the role of the immune system at the implantation site
By Gil Mor, I. Cardenas, V. Abrahams, S. Guller. Annals of the New York Academy of Sciences, 2011
1,059 citations recorded by the source corpus.
The concept that pregnancy is associated with immune suppression has created a myth of pregnancy as a state of immunological weakness and, therefore, of increased susceptibility to infectious diseases. A challenging question is whether the maternal immune system is a friend or a foe of pregnancy. In this review, we discuss data associated to the role of the immune system during pregnancy. We propose a new paradigm in terms of the fetal–maternal immune interaction as well as the immunological response of the mother to microorganism. Our challenge is to better understand the immunology of pregnancy in order to deliver the appropriate treatment to patients with pregnancy complications as well as to determine public policies for the protection of pregnant women during pandemics.
Subfields: Immunology, Obstetrics and Gynecology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/76d0506878608d776da2d7374f7168ea1d68854f
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Citations in the corpus
- Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production (2013, background): “Irg1 is also highly expressed in the early events leading to implantation in the pregnant uterus (13, 14), the specific phase in which a high level of inflammatory cytokines are secreted by the endometrial cells as well as by cells of the immune system that are recruited to the site of implantation ”
- Macrophage Polarization in Physiological and Pathological Pregnancy (2019, background): “These macrophages are involved in extensive remodeling of the uterine vasculature, which is required to supply adequate placental–fetal blood (40, 41).”