The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node.

By M. Sixt, N. Kanazawa, Manuel Selg, T. Samson, G. Roos, D. Reinhardt, R. Pabst, M. Lutz, L. Sorokin. Immunity, 2005

774 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/535db8b61a7d863f6b83695304bf6cec6a1c63f1

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In Immunology

1. A. Luster
2. J. Cyster
3. F. Batista
4. Naomi E. Harwood
5. O. Joffre
6. M. Nolte
7. R. Spörri
8. R. Mebius

In Immunology and Allergy

1. J. Cyster
2. F. Batista
3. B. Hinz
4. H. Wiig
5. M. Swartz
6. Naomi E. Harwood
7. A. Luster
8. Nikolaos G. Frangogiannis

Citations in the corpus

• Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns (2010, background): “Soluble proteins can directly reach the B and T cell regions through conduit”
• Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells (2007, background): “The antibody clone ER-TR7, which is widely used as FRC-specific reagent in histology, was not TRC specific by flow cytometry, consistent with its reported extracellular localization in conduit”
• The who, how and where of antigen presentation to B cells (2009, background): “5 nm) are allowed to move towards the HEV through the intricate meshwork of fibroblastic reticular cell (FRC)-lined collagenous conduits that are associated with DC”
• Orchestrating the orchestrators: chemokines in control of T cell traffic (2008, background): “The lymph node conduit system, which communicates with the HEV perivenular space”
• Structure and function of the spleen (2005, background): “This, in turn, is surrounded by a basement membrane and then by reticular fibroblast”
• The impact of the extracellular matrix on inflammation (2010, background): “In addition, specialized ECM structures, which combine features of both the basement membrane and the interstitial matrix, form the reticular fibre network of secondary lymphoid organ”
• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “The reticular conduit system in both lymph nodes and splenic white pulp could play an important role in this respect, as resident DCs extend processes into the lumen of this network and are thereby able to sample the content of the interstitial fluid and blood, respectively (87, 88).”
• Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma (2016, positive): “Since this molecule is small enough that it would be expected to be able to drain via lymph to the dLN directly (Sixt et al., 2005), its accumulation in these other myeloid populations in a CCR7-dependent manner very much points to ongoing intratumoral uptake by migratory DC and subsequent…”
• Dendritic-cell trafficking to lymph nodes through lymphatic vessels (2005, background): “The expression and activation of β 1 -integrins, which mediate the interaction of DCs with extracellular-matrix component”