Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

By L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia, S. Dulawa, N. Weisstaub, James J. Lee, R. Duman, O. Arancio and 2 more. Science, 2003

4,342 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/528587b53dac8c3c133f7be325c94a747170887a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Wei Deng
4. R. Hen
5. Guo-li Ming
6. R. Duman
7. James Bradley Aimone
8. E. Gould

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. Wei Deng
5. R. Hen
6. James Bradley Aimone
7. R. Duman
8. E. Gould

Citations in the corpus

• Circuit-breakers: optical technologies for probing neural signals and systems (2007, background): “, the generation of new neurons in the hippocampus has been linked to the therapeutic efficacy of antidepressant”
• Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Adult neurogenesis has also been suggested to play a critical role in mood regulation, another hippocampal-associated higher brain function (Santarelli et al., 2003; Sahay and Hen, 2007).”
• Adolescent cortical development: a critical period of vulnerability for addiction. (2007, background): “Antidepressant drugs that target serotonin and norepinephrine systems, both of which change during adolescence, increase hippocampal neurogenesis (Malberg and Duman, 2003; Santarelli et al., 2003).”
• Major depressive disorder. (2008, positive): “esis but also supports survival of newborn neurons [61].”
• Adult neurogenesis and the plasticity of the dentate gyrus network (2011, methodology): “…neurogenesis using pharmacology, irradiation or transgenesis impairs specific forms of hippocampus-dependent learning and behavior in rodents (Shors et al., 2001; Santarelli et al., 2003; Abrous et al., 2005; Saxe et al., 2006; Winocur et al., 2006; Dupret et al., 2008; Clelland et al., 2009).”
• GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells. (2005, positive): “Conclusion The discovery that neurogenesis occurs in the adult mammalian hippocampus has been a breakthrough in modern neuroscience, with various studies suggesting that adult hippocampal neurogenesis is involved in memory and emotion (Shors et al., 2001; Santarelli et al., 2003; Abrous et al., 2005”
• Adult hippocampal neurogenesis in depression (2007, background): “The most compelling evidence linking adult hippocampal neurogenesis with antidepressants comes from our laboratory, in a study demonstrating that neurogenesis is necessary for the effects of imipramine, a tricyclic antidepressant, and fluoxetine, a selective serotonin reuptake inhibitor, in two mous”
• Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, positive): “Moreover, neurogenesis was found to be required for many of the behavioral effects of antidepressants (Santarelli et al., 2003).”
• Serotonin and brain function: a tale of two receptors (2017, background): “in the hippocampus) is a 5-HT1AR-mediated effect (Gould, 1999; Huang and Herbert, 2005; Malberg et al., 2000; Santarelli et al., 2003); however, other 5-HT receptors (e.”
• Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus (2007, background): “Because suppression of adult neurogenesis after these manipulations is typically incomplet”
• Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “…and behavior by using a variety of methods in mice and rats to block adult neurogenesis, including cytostatic drugs, brain irradiation, and genetic ablation of dividing progenitors throughout the adult brain (e.g., Shors et al. 2001; Santarelli et al. 2003; Saxe et al. 2006; Winocur et al. 2006).”
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, methodology): “…subjected to the NSFT. Twenty-four hours afterwards, the same groups of mice were subjected to the TST. Latency to feed in the NSFT and length of immobility in the TST were rated as previously described (Santarelli et al., 2003; Svenningsson et al., 2006), with investigators blind to genotypes.”
• Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months (2011, background): “The most commonly prescribed antidepressant medications, selective serotonin reuptake inhibitors and tricyclic antidepressants, have been shown to increase the rate of hippocampal neurogenesis in rodents (49, 50) and nonhuman primates (22).”