Circuit-breakers: optical technologies for probing neural signals and systems

By Feng Zhang, A. Aravanis, Antoine Adamantidis, L. Lecea, Karl Deisseroth. 2007

603 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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In Cognitive Neuroscience

Citations in the corpus

Neural syntax: cell assemblies, synapsembles and readers (2010, neutral): “…inactivation ofmultiple single neurons and synapses by light activation are on the horizon (Boyden et al., 2005; Deisseroth et al., 2006; Luo et al., 2008; Miesenböck, 2009; Zhang et al., 2007), discussion of their potential use in identifying assemblies, neural words, and sentences is warranted.”
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing (2012, background): “The best-known prototypes for the application of optical control in neurons include the neuron-activating cation channel channelrhodopsin-2 (ChR2) 1–3 , and the neuron-silencing chloride transporter halorhodopsin (NpHR) 4,5 and proton pump archaerhodopsin-3 (Arch) 6 .”
Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons (2009, methodology): “optogenetical experiments using SARE as a driver for conditional Cre recombinase such as hormone-activated CreERT2 (31), or for channelrhodopsins/halorhodopsins (32), with a view to manipulating specific gene expression or neuronal excitability in an activated ensemble of neurons within a circuit.”
Molecular and cellular approaches for diversifying and extending optogenetics. (2010, methodology): “…we observed potent 250 pA outward photocurrents in virally transduced cells—still more than 6-fold larger than the firstobserved NpHR currents with yellow light (Figure 3A), and maintaining the characteristic step-like, stablekinetics typical of NpHR (Zhang et al., 2007a) (Figure 1; Figure S1).”
Transcranial pulsed ultrasound stimulates intact brain circuits. (2010, methodology): “Optogenetic-based methods using lightactivated ion channels or transporters offer unrivaled spatial resolution but require genetic alteration (Szobota et al., 2007; Zhang et al., 2007).”
Active dendrites: colorful wings of the mysterious butterflies. (2008, neutral): “38 Zhang, F. et al. (2007) Circuit-breakers: optical technologies for probing neural signals and systems. Nat. Rev. Neurosci. 8, 577– 581 39 Trimmer, J.S. and Rhodes, K.J. (2004) Localization of voltagegated ion channels in mammalian brain. Annu. Rev. Physiol. 66, 477–519 40 Kim, J. et al. (2007) Re”
Highly Selective Receptive Fields in Mouse Visual Cortex (2008, background): “Finally, the ability to make precise manipulations of neural activity in defined cell populations (Boyden et al., 2005; Tan et al., 2006; Zhang et al., 2007b) should allow direct causal tests of models of cortical processing.”
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “Novel experimental systems, such as the \brainbow mouse" (Livet et al., 2007) and optogenic tools (Zhang et al., 2007) might help in the elucidation of these networks and their malfunction during stress and depression.”
A disinhibitory microcircuit for associative fear learning in the auditory cortex (2011, methodology): “To test further whether disinhibition specifically during the foot shock contributes to fear learning, we used channelrhodopsin-2 (ChR-2”