microRNA functions.

By Natascha Bushati, Stephen M Cohen. Annual Review of Cell and Developmental Biology, 2007

2,456 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/51e6f241a1a787272877c8fdea14e84f5e9df741

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Citations in the corpus

MicroRNA control in the immune system: basic principles. (2009, background): “…physiology of the system, namely control exerted by microRNAs (miRNAs). miRNAs are endogenously encoded single-stranded RNAs of about 22 nt in length that play essential roles in animals and plants, in a large variety of physiological contexts (Ambros, 2004; Bartel , 2004; Bushati and Cohen, 2007).”
Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development (2009, neutral): “Proc Natl Acad Sci USA 98(9):5116–5121.”
Translational control of long-lasting synaptic plasticity and memory. (2009, neutral): “The discovery of microRNAs (miRNAs) has revolutionized the biology field. miRNAs are a family of small RNAs ($21 nucleotides long) that regulate as much as 50% of all gene expression posttranscriptionally , in different phyla (Bushati and Cohen, 2007).”
Predicting effective microRNA target sites in mammalian mRNAs (2015, methodology): “…expansive sets of computational predictions (e.g., all mRNAs with a 6mer site) to relatively small sets of biochemically supported predictions ( Chi et al., 2009 ; Lipchina et al., 2011 ; Loeb et al., 2012 ; Grosswendt et al., 2014 ; Tan et al., 2014 ). mRNAs with expression signals…”
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis (2010, background): “Thus, miR-21 appears to function in an amplifying circuit to enhance TGF-1 signaling events and to promote fibrotic lung diseases in which TGF- plays a contributory role, including IPF. miRNAs normally have multiple targets (Bushati and Cohen, 2007; Lodish et al., 2008).”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “miRNAs are involved in a broad range of developmental and physiological processes (Bushati and Cohen 2007); thus, their deregulation is closely linked to human diseases, such as cancer (Chang and Mendell, 2007; Garzon et al.”
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “One group includes short RNAs less than 200 nucleotides (nt) in length, such as microRNAs (miRNAs) that are small RNA (sRNA) molecules around 21–24 nt in length, as well as other classes such as piwi-interacting RNAs (piRNAs) [5].”
MicroRNA Functions in Stress Responses (2010, neutral): “As the name implies, miRNAs are short RNAs of 22 nucleotides that modulate the stability and/or translational potential of their mRNA targets (Figure 1A) (Bushati and Cohen, 2007; Carthew and Sontheimer, 2009; Fabian et al., 2010).”
Development of microRNA therapeutics is coming of age (2014, neutral): “Indeed, miRNAs have been implicated in the regulation of many cellular and developmental processes (Kloosterman & Plasterk, 2006; Bushati & Cohen, 2007; Braun & Gautel, 2011).”
Serum MicroRNAs Are Promising Novel Biomarkers (2008, background): “Finally, these 20–22 nucleotides are incorporated into a composite machinery, which promotes partial duplex formation between the short RNA and the 39 untranslated regions (UTR) of targeted mRNAs, resulting typically in mammals in translational silencing [6,7].”
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades (2011, background): “…by one or more miRNAs in one or more cellular contexts (3,4) it is not surprising that miRNAs are involved in almost all biological processes, ranging from development to metabolic regulation and cancer (5–7). miRNAs must be detected and annotated before their biological functions can be unraveled.”