Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development

By Zhe Ji, J. Y. Lee, Zhenhua Pan, B. Jiang, Bin Tian. Proceedings of the National Academy of Sciences of the United States of America, 2009

597 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7f38a1cbf611e8c7b75882c52d132ffc38a5db78

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In Molecular Biology

1. Phillip A. Sharp
2. Margaret S. Ebert
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Citations in the corpus

• Ending the message: poly(A) signals then and now. (2011, background): “Several independent studies have revealed the remarkable fact that either levels of cell proliferation or developmental stage can cause a shift in APA from more distal to more proximal PAS selection (Sandberg et al. 2008; Ji et al. 2009; Mayr and Bartel 2009).”
• Mechanisms and consequences of alternative polyadenylation (2011, unknown): “…in 30 UTR length, while 30 UTRs tend to be longer during late develop- 854 Molecular Cell 43, September 16, 2011 ª2011 Elsevier Inc. mental stages and cell differentiation (Ji et al., 2009; Ji and Tian, 2009; Mayr and Bartel, 2009; Sandberg et al., 2008; Shepard et al., 2011; Wang et al., 2008a).”
• A quantitative atlas of polyadenylation in five mammals (2012, background): “However, numerous studies have reported dynamic behavior of APA; 39UTR length can vary during development (Ji et al. 2009; Mangone et al. 2010), for example, and some 39UTRs become truncated in cancer samples (Sandberg et al. 2008).”
• Interplay between splicing and transcriptional pausing exerts genome-wide control over alternative polyadenylation (2021, background): “For example, gradual decrease of 3ʹ end processing factors during early embryonic development produces slippage toward downstream PAS [6].”
• Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells (2009, unknown): “Recent reports propose that a change in 3 0 UTR length by means of APA is a coordinated mechanism for altering expression of many genes during T cell activation (Sandberg et al., 2008), neuronal activation (Flavell et al., 2008) or embryonic development (Ji et al., 2009).”
• Roles for microRNAs in conferring robustness to biological processes. (2012, background): “In a coherent FFL, component A inhibits (or activates) component C and activates (or inhibits, respectively) component B, which is another repressor of component C.”
• Evolution of microRNA diversity and regulation in animals (2011, background): “This weakening of activity occurs when proximal polyadenylation signals are recognized less effectively, which is presumably due to lowered expression of key polyadenylation machinery gene”