Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

By E. Meylan, J. Curran, Kay Hofmann, D. Moradpour, M. Binder, Ralf Bartenschlager, J. Tschopp. Nature, 2005

2,549 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b3aea275ddb67cdfd947e89a1ca5041cc0669e4

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Citations in the corpus

Flaviviridae :T he Viruses and Their Replication (2007, background): “First, NS34A cleaves and inactivates the mitochondrial outer membrane protein alternately known as IPS-1, MAVS, VISA, or Cardif (397,486).”
The specific and essential role of MAVS in antiviral innate immune responses. (2006, background): “The mitochondrial localization of MAVS is essential for its signaling function, and this property is exploited by hepatitis C virus, which deploys the NS3/4A serine protease to cleave MAVS off the mitochondria to evade the host innate immune responses (Freundt and Lenardo, 2005; Li et al., 2005; Mey”
Innate Immunity to Virus Infection (2009, background): “IPS-1 is known to be cleaved by the HCV protease NS3 ⁄ 4A in HCV-infected cells (41, 46).”
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity (2007, background): “Indeed, hepatitis C virus targets IPS-1 through the actions of the viral NS3/4A protease, which cleaves IPS-1 to inactivate its signaling properties (15, 26, 27).”
MDA5/RIG-I and virus recognition. (2008, background): “RIG-I and MDA5 associate with an adaptor protein, IFN-b promoter stimulator 1 (IPS-1; also known as MAVS, VISA or CARDIF), which also contains a CARD [21–24].”
NF-κB and the immune response (2006, background): “Recently, a CARD-containing protein, variably named CARDIF, IPS1, MAVS and VISA, has been implicated downstream of RIG-I; however, the link between this protein and IKKb is unclear (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005).”
Structural insights into RNA recognition by RIG-I (2011, positive): “Upon binding and activation by viral dsRNA or triphosphorylated RNA, RIG-I recruits the adaptor IPS-1 (also known as MAVS, CARDIF or VISA) on the outer membrane of the mitochondria through the CARDs (Fujita et al., 2007; Meylan et al., 2005).”