Replication validity of genetic association studies
By John P. A. Ioannidis, E. Ntzani, Thomas A. Trikalinos, D. Contopoulos-Ioannidis. Nature Genetics, 2001
1,912 citations recorded by the source corpus.
Subfields: Genetics, Statistics and Probability
View Paper: https://www.semanticscholar.org/paper/5157893bace99c321a9582c2df8b4df3ae48985a
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In Genetics
- John P. A. Ioannidis
- Jonathan Marchini
- David Altshuler
- Peter Donnelly
- Joel Hirschhorn
- Eric S. Lander
- Matthew Stephens
- Lon R. Cardon
In Statistics and Probability
- Marcus Munafò
- Daniele Fanelli
- John P. A. Ioannidis
- Douglas B. Kell
- David Broadhurst
- Peter Donnelly
- John-Dylan Haynes
- Robert M. Plenge
Citations in the corpus
- Candidate gene studies of ADHD: a meta-analytic review (2009, background): “Despite such eVorts, the search for susceptibility genes for ADHD, like those for other complex traits (Ioannidis et al. 2001; Lohmueller et al. 2003), has yielded largely inconsis-”
- Genome-wide strategies for detecting multiple loci that influence complex diseases (2005, result): “Our results bear on the reported failure to replicate association studies upon follow-u”
- 'Racial' differences in genetic effects for complex diseases (2004, neutral): “others 4,091 (14) 4,003 (13) 0 88 (1) 0 1,071 (1) 2 Lung cancer GSTM1 (gene deletion); –/– vs.”
- Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease (2003, result): “This result is consistent with the main conclusion of a recent review of association studie”
- Heterogeneity testing in meta‐analysis of genome searches (2005, result): “This may be particularly prominent in genetics, where there is evidence that studies may often give very different results and exploratory, hypothesis-generating epidemiologic findings may not be replicated across several studies [Ioannidis et al., 2001; Ioannidis, 2003].”
- Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. (2005, result): “Our finding that the majority of previous association studies in RA may represent false-positive results is consistent with the published literature of other complex genetic diseases (Ioannidis et al. 2001; Lohmueller et al. 2003).”
- Array comparative genomic hybridization and its applications in cancer (2005, result): “As with other types of statistical study, these results require validation on independent sets to control for the possibility of unanticipated systematic factors in the initial group”