Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

By K. Lohmueller, C. Pearce, Malcolm Pike, Eric S. Lander, Joel Hirschhorn. Nature Genetics, 2003

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The future of association studies: gene-based analysis and replication. (2004, methodology): “A number of groups have developed methods for selecting haplotype-tagging SNPs from a larger set of SNPs (Byng et al. 2003; Chapman et al. 2003; Weale et al. 2003; Lowe et al. 2004; Zhang et al. 2004).”
Predicting the effects of amino acid substitutions on protein function. (2006, background): “A list of common nsSNPs that have been associated with complex disease has been compiled (28, 37).”
Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits (2007, background): “SNPs that reach statistical significance are likely to include those for which effect size estimates are inflated (this is the winner’s curse phenomenon) [36], and thus we proceeded to replicate our top association signals in additional large samples.”
Molecular genetics of attention-deficit/hyperactivity disorder. (2005, neutral): “Moreover, they suggest one explanation for the frequent failure to replicate initial reports of association: many individual studies might be underpowered to find significant associations if the effects are modest (Ioannidis et al 2001; Lohmueller et al 2003).”