Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.

By H. Daitoku, M. Hatta, Hitomi Matsuzaki, S. Aratani, T. Ohshima, M. Miyagishi, T. Nakajima, A. Fukamizu. Proceedings of the National Academy of Sciences of the United States of America, 2004

625 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/51312bc42c8c8bb27df4946817c2a253b2e7be40

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In Aging

1. D. Sinclair
2. C. Kenyon
3. L. Guarente
4. E. Verdin
5. A. Brunet
6. F. Picard
7. E. L. Greer
8. R. Mostoslavsky

In Geriatrics and Gerontology

1. D. Sinclair
2. L. Guarente
3. E. Verdin
4. C. Kenyon
5. F. Picard
6. R. Mostoslavsky
7. W. Gu
8. F. Alt

In Molecular Biology

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2. L. Guarente
3. D. Accili
4. A. Brunet
5. D. Sinclair
6. Stefanie Dimmeler
7. E. Verdin
8. F. Picard

Citations in the corpus

• Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. (2009, background): “Factors belonging to the Foxo subfamily have been shown to inhibit ROS generation by enhancing the activities of MnSOD and catalase (27, 28).”
• FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. (2005, methodology): “We replaced six lysine residues corresponding to proposed FoxO acetylation sites (K242, K245, K259, K262, K271, and K291) (Brunet et al., 2004; Daitoku et al., 2004) with arginine to prevent acetylation (henceforth KR series), and with glutamine to mimic it (Luo et al.”
• Calorie restriction--the SIR2 connection. (2005, background): “However, there may be a wrinkle in the case of Foxo regulation; certain Foxo targets, such as the DNA repair gene GADD45, appeared to be upregulated by Sirt1 (Brunet et al., 2004; Daitoku et al., 2004; van der Horst et al., 2004), although the mechanism for this is not yet understood.”
• FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “SIRT1 directly catalyses the deacetylation of FOXO factors in vitro and participates in the deacetylation of these factors within cells (Brunet et al., 2004; Daitoku et al., 2004; Motta et al., 2004; Van Der Horst et al., 2004; Frescas et al., 2005; Yang et al., 2005b).”
• FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. (2011, background): “Several studies described the acetylation of FoxO proteins at sites corresponding to K242, K245 and K262 of FoxO1 [121,122].”
• FoxO transcription factors in the maintenance of cellular homeostasis during aging. (2008, background): “In addition to the PI3K/Akt pathway, the other major signaling modules that directly regulate the activity of the FoxO factors include the stress-activated Jun-N-terminal kinase (JNK), the mammalian ortholog of the Ste20-like protein kinase (MST1), and the deacetylase Sirt1 (Figure 1) [9–11,13,14,15”
• SIRT1 controls endothelial angiogenic functions during vascular growth. (2007, background): “However, the mode of Foxo regulation by SIRT1 remains controversial, with some data suggesting that deacetylation decreases (Motta et al. 2004) and others that it increases Foxo activity (Brunet et al. 2004; Daitoku et al. 2004; van der Horst et al. 2004).”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “For example, SirT1 deacetylates FOXO, which in turn shifts FOXO target selection toward stress-response genes (Brunet et al., 2004; Daitoku et al., 2004; Giannakou and Partridge, 2004; Motta et al., 2004).”