Protease degradomics: A new challenge for proteomics

By C. López‐Otín, Christopher M. Overall. Nature reviews. Molecular cell biology, 2002

769 citations recorded by the source corpus.

Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/50c6e620a45faa87eba292279491bbc8845dd6c8

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Citations in the corpus

The genome of the blood fluke Schistosoma mansoni (2009, neutral): “Proteolytic enzymes (proteases), making up an organism’s ‘degra-dome’ 28 , operate in virtually every biological and pathological phenomenon 29 and are proven drug targets in diverse biomedical contexts 30,31 .”
Human and mouse proteases: a comparative genomic approach (2003, background): “The availability of the human and mouse euchromatic genomic sequences has raised the possibility of addressing global questions about the degradome — the complete set of proteases that are expressed at a specific moment or circumstance by a cell, tissue or organis”
Strategies for MMP inhibition in cancer: innovations for the post-trial era (2002, background): “The human genome sequence has revealed more than 500 genes that encode proteases or protease-like proteins, with a large number being associated with tumour processe”
Emerging roles of proteases in tumour suppression (2007, background): “jpg" NDATA ITEM> ]> Proteases have fundamental roles in multiple biological processes and are associated with a wide variety of pathological conditions, including cance”
Cleavage Entropy as Quantitative Measure of Protease Specificity (2013, background): “As parameters at the level of sequence [81], structure [18] and conformational flexibility [82] are known to influence protease specificity, a direct quantification of substrate promiscuity of proteases will help to distinguish individual contributions to this phenomenon [83] and thereby support str”
Targeting proteases: successes, failures and future prospects (2006, background): “Complexity of protease signalling To identify the role of a given protease in a given biological process and to understand protease signalling in health and disease one needs to know the identity of a protease's physiological substrates — that is, the protease degradom”
Proteomics: the first decade and beyond (2003, background): “In fact, the study of proteases and their substrates and inhibitors in an organism has been called “degradomics&rdquo”
Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness (2004, background): “MMPs have increased expression and activation in almost all human cancer”
Matrix metalloproteinases and the regulation of tissue remodelling (2007, methodology): “Biochemical challenges include the visualization of MMP activity in living cells and tissues, the development of non-cleavable substrates and the determination of the complete in vitro MMP degradome”