Matrix metalloproteinases and the regulation of tissue remodelling

By Andrea Page-McCaw, Andrew J. Ewald, Zena Werb. Nature reviews. Molecular cell biology, 2007

2,884 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/b0b0bbf17c8d2757f5372797b62f6afc6d7d3496

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Pengfei Lu
2. Zena Werb
3. Gillian Murphy
4. R. Khalil
5. Valerie M. Weaver
6. Xi Wang
7. W. Parks
8. Hideaki Nagase

In Hematology

1. Gillian Murphy
2. Hideaki Nagase
3. Valerie M. Weaver
4. W. Parks
5. Zena Werb
6. Pengfei Lu
7. H. Ra
8. K. Takai

In Immunology

1. Pengfei Lu
2. Valerie M. Weaver
3. V. Plaks
4. Richard J. Johnson
5. R. Khalil
6. B. Psaila
7. R. Hynes
8. Zena Werb

Citations in the corpus

• Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “tissue remodeling and organ development (Page-McCaw et al., 2007), in the regulation of inflammatory processes (Parks et al.”
• A tense situation: forcing tumour progression (2009, background): “Force has a fundamental role in directing stem cell fate and in dictating embryonic developmen”
• Progress in matrix metalloproteinase research. (2008, background): “, 1995) to the morphogenesis of specific tissues, including lung, bone and mammary gland (reviewed by Vu and Werb, 2000; Page-McCaw et al., 2007).”
• Otolith Biochemistry—A Review (2019, background): “Plasmin, then, can act to activate a broad range of collagenases, the matrix metalloproteinases, a family that play key roles in development and resorption of biomineralized tissues (Somerville et al., 2003; Visse and Nagase, 2003; Page-McCaw et al., 2007).”
• Control of matrix metalloproteinase catalytic activity. (2007, background): “…not be viewed solely as proteinases of matrix catalysis, but rather as extracellular processing enzymes involved in regulating cell-cell and cell-matrix signaling events, quite typically, gain-of-function processing of latent proteins (Page-McCaw et al., 2007; Parks, 1999; Vu and Werb, 2000).”
• Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers (2016, background): “First, during tissue remodeling in the post-stroke recovery and healing phase, MMPs digest old ECM so that new ECM and tissue can be generated.(2,187,191) Second, during ECM digestion, MMPs (mainly MMP-7 and MMP-9, but also MMPs-1, -2, -3, -10, and -11) increase the availability of growth factors (e”
• Extracellular matrix dynamics in development and regenerative medicine (2008, background): “Because the role of MMPs in both development and disease has recently been reviewed (Page-McCaw et al., 2007), we focus primarily on cathepsins and serine proteases such as urokinase plasminogen activator (uPA).”
• Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “Indeed, the ECM is a dynamic and versatile compartment and by modulating the production, degradation, and remodeling of its components, it can support organ development, function and repairing [4,5].”
• The metastatic niche: adapting the foreign soil (2009, background): “MMPs are instrumental in degrading ECM components during inflammatory responses and tissue repair as well as in primary tumour growt”