Microarray Analysis of Pseudomonas aeruginosa Quorum-Sensing Regulons: Effects of Growth Phase and Environment

By V. Wagner, D. Bushnell, L. Passador, A. Brooks, B. Iglewski. Journal of Bacteriology, 2003

945 citations recorded by the source corpus.

Subfields: Genetics, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/508f9b129c9edd52ffbe9f1176dcd98062340f39

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. B. Bassler
2. Christopher M. Waters
3. Lindsay M. Aye
4. Kelli L. Palmer
5. Robert E. W. Hancock
6. Jan Michiels
7. M. Whiteley
8. Bernd H. A. Rehm

In Microbiology

1. Lindsay M. Aye
2. Kelli L. Palmer
3. Robert E. W. Hancock
4. M. Whiteley
5. Bernd H. A. Rehm

In Molecular Biology

1. M. Givskov
2. Søren Molin
3. Christopher M. Waters
4. B. Bassler
5. Lindsay M. Aye
6. Kelli L. Palmer
7. K. Drescher
8. Robert E. W. Hancock

Citations in the corpus

• Quorum sensing: cell-to-cell communication in bacteria. (2005, background): “D ow nl oa de d fr om a rj ou rn al s. an nu al re vi ew s. or g by U ni fo rm ed S er vi ce s U ni ve rs ity -”
• A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms (2006, background): “aeruginosa have been shown to be quorum sensingregulated (Wagner et al., 2003), and it is possible that mutations in the quorum-sensing control systems might affect many gene activities which have roles in biofilm development, the present study suggests that one of the quorum sensing-controlled fact”
• Nutritional Cues Control Pseudomonas aeruginosa Multicellular Behavior in Cystic Fibrosis Sputum (2007, background): “aeruginosa cell-cell signaling (quorum sensing) is also influenced by nutritional cues (9, 39, 63).”
• Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation (2008, background): “This resulted in a downregulation of more than 50 genes (Table 1) that are part of the respective regulons (45, 54).”
• Exploiting Quorum Sensing To Confuse Bacterial Pathogens (2013, background): “aeruginosa growth is not affected by lasR mutations under traditional laboratory conditions, LasR is known to regulate many genes involved in central metabolism (341, 342).”
• Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa (2006, background): “Considerable overlap also occurs between genes expressed in the biofilm mode of growth and genes controlled by quorum sensing (26, 55, 63).”
• Cell Death in Pseudomonas aeruginosa Biofilm Development (2003, background): “TolA is both differentially expressed in biofilms (66) and controlled by cellcell signaling (64).”
• The application of biofilm science to the study and control of chronic bacterial infections. (2003, neutral): “When we examine the proteome of cells in biofilms (14) or analyze the biofilm phenotype by using DNA arrays (26), we find that sessile cells express many genes that are never expressed in planktonic cells, and vice versa.”
• A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation (2013, background): “Because LasR activates expression of rhlR, deletion of lasR reduces expression of both LasR- and RhlR-regulated target genes (11, 17).”