Cell Death in Pseudomonas aeruginosa Biofilm Development

By J. Webb, L. Thompson, Sally James, T. Charlton, T. Tolker-Nielsen, B. Koch, M. Givskov, S. Kjelleberg. Journal of Bacteriology, 2003

636 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/82ff3802edaaaa71fb35f2b22246f20ea65a5348

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Citations in the corpus

Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix (2009, background): “Cells also undergo autolysis in biofilm microcolonies [19], but it is unclear whether autolysis contributes to eDNA and biofilm development.”
Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal (2011, background): “Active dispersal from biofilms is typically (but not in all species) preceded by localized death and lysis of cells in the centre of mature biofilm structure”
The Social Lives of Microbes (2007, background): “However, a complication here is that in P. aeruginosa cell death involves a genomic prophage (Webb et al. 2003).”
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “aeruginosa showed extensive cell death as well as cell lysis in the centers of macrocolonies (347).”
What is the role and nature of programmed cell death in phytoplankton ecology? (2006, background): “Signalling within bacterial biofilms can lead to PCD via quorum-sensing (Oleskin et al , 2000 ), or through the induction of prophages and autotoxins (Webb et al , 2003 ).”
Bacterial biofilms: from the Natural environment to infectious diseases (2004, background): “Liquification has been attributed to lysis of a subpopulation due to prophage-mediated cell deat”
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses (2010, background): “…superinfecting and lysing P. aeruginosa (bacteriophage Pf4) was detected in the fluid effluent from P. aeruginosa biofilms cultured in flow cells (Webb et al., 2003), and the amount of bacteriophage activity in the effluent paralleled the degree of cell death seen in the biofilm (Kirov et al.,…”
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa (2006, methodology): “aeruginosa biofilms were previously linked to the appearance of infectious bacteriophage in the biofilm runoff (66).”
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms (2006, background): “Quinolone compounds have previously been shown to induce prophages in bacteria (Phillips et al., 1987; Froshauer et al., 1996), and recent studies by Webb et al. (2003) and Hentzer et al. (2004) suggested that quorum sensing-regulated DNA release might be linked to phage induction in biofilms…”
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, background): “Voids within the biofilm are also created by cell death, serving as an additional dispersal mechanism that frees resident live bacteria, as shown by studies in P. aeruginosa (Webb et al. 2003).”
Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms (2008, background): “It has been reported that prophage-mediated cell death is an important mechanism in the differentiation and dispersal of biofilms [54,55].”
The biofilm matrix (2010, background): “One intriguing theory is that cell lysis and subsequent local decomposition of the EPS matrix might be advantageous for the biofilm population, creating new pores and channels that improve nutrient acces”
Critical review on biofilm methods (2017, background): “…observe the existence of localized cell death in biofilms and their regulation (Asally et al., 2012; Ghosh et al., 2013; Guilbaud et al., 2015; Webb et al., 2003), and to assess the effect of several antimicrobials on cell viability (Bridier et al., 2012; Doroshenko et al., 2014; Marchal et…”
Antibiotic resistance of bacterial biofilms. (2010, background): “bacteria may be up to 100 – 1000 fold higher compared to planktonic bacteria (21) 115”
Microbial Biofouling: Unsolved Problems, Insufficient Approaches, and Possible Solutions (2011, background): “Dispersion by induction of a prophage, followed by cell death and subsequent cell cluster disaggregation has been observed (Webb et al. 2003).”