Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

By L. V. Borovikova, S. Ivanova, Minghuang Zhang, Huan Yang, G. Botchkina, Linda R. Watkins, Haichao Wang, N. Abumrad, J. Eaton, Kevin J. Tracey. Nature, 2000

3,990 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Neurology

View Paper: https://www.semanticscholar.org/paper/5052790a52267b64dfefecf5e2cba7b7b4f001cb

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Citations in the corpus

Pathological bacterial translocation in liver cirrhosis. (2014, background): “However, vagal nerve stimulation attenuates inflammatory response to endotoxin [157] and intestinal inflammation [158], protecting against burn-induced intestinal injury [159].”
Central nervous system injury-induced immune deficiency syndrome (2005, neutral): “In response to acetylcholine, activated macrophages swiftly decrease the production of pro-inflammatory cytokines such as TNFα, IL-1β and IL-18, but not the anti-inflammatory cytokine IL-10 (Ref”
Sepsis: current dogma and new perspectives. (2014, background): “…or splenic nerves, genetically ablating a7nAChR, or pharmacologically inhibiting signals along this pathway all enhance cytokine release and the increase the severity of of lethal shock and tissue injury (Bernik et al., 2002; Borovikova et al., 2000; Rosas-Ballina et al., 2008; Wang et al., 2003).”
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, background): “Additional evidence suggests that the parasympathetic nervous system modulates immune responses at a regional level through both the efferent and afferent fibers of the vagus nerve, enabling it to prevent excessive inflammation (Borovikova et al., 2000; Sternberg, 2006; Tracey, 2009).”
Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. (2006, background): “During an infection, the proinflammatory response that is essential to mounting an immune defense is normally contained by cortisol and also by parasympathetic activity [4,7].”
The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation (2003, background): “We recently demonstrated the existence of a parasympathetic pathway of modulation of systemic and local inflammatory responses (16,69), which focuses attention on neural immunomodulatory mechanisms via the vagus nerve.”
The inflammatory reflex (2002, background): “Cholinergic anti-inflammatory pathway Our understanding of the basic mechanisms that regulate inflammation has been advanced by the identification of a neural mechanism that inhibits macrophage activation through parasympathetic outflo”
Brain-gut interactions in inflammatory bowel disease. (2013, background): “More recently, an anti-inflammatory role of VN efferents through the cholinergic anti-inflammatory pathway has been reported (25).”
The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis (2017, background): “The PNS acts through acetylcholine receptors in immune cells to down-regulate pro-inflammatory cytokine production (Borovikova et al., 2000; Marsland, Gianaros, Prather, Manuck, 2007) and circulating markers of inflammation (Sloan et al., 2007; Pavlov & Tracey, 2005).”
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018, background): “As stated earlier, ACh released at the distal end of VN efferents decreases the production of proinflammatory cytokines, such as TNF-α (188).”