Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

By Annapoorni Rangarajan, C. Talora, R. Okuyama, Michael Nicolas, C. Mammucari, Heysun Oh, J. Aster, S. Krishna, D. Metzger, P. Chambon and 4 more. EMBO Journal, 2001

945 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4f3d533abe1cd59b7032b5fcd907b81582dd2cbf

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Citations in the corpus

• Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “The canonical Notch pathway is also crucial during the early step of basal cell commitment to spinous cell”
• Lost in transcription: p21 repression, mechanisms, and consequences. (2005, background): “cells (77), it was also shown that in endothelial cells, Notch activation led to p21 repression and to cell cycle arrest (78).”
• Epidermal stem cells of the skin. (2006, background): “During the early stage of epidermal stratification, Notch1 is expressed and active in the basal and suprabasal cells of the epidermis and sebaceous glands (Okuyama et al. 2004, Rangarajan et al. 2001) (Figure 7b).”
• Notch signaling: simplicity in design, versatility in function (2011, neutral): “, 2006), p21 (Rangarajan et al., 2001), Snail (Sahlgren et al.”
• Notch1 functions as a tumor suppressor in mouse skin (2003, background): “The role of Notch signaling in mammalian skin is less well characterized and is mainly based on in vitro studies, which suggest that Notch signaling induces differentiation in mammalian ski”
• PI5P4Kγ functions in DTX1-mediated Notch signaling (2018, background): “For example, Notch loss-offunction mutations give rise to aortic valve disease and keratinocyte hyperplasia (7, 8).”
• Epithelial stem cells: turning over new leaves. (2007, neutral): “Thus, it came as a surprise when Notch was implicated as a tumor suppressor in the cornea and epidermis, as judged by the fact that loss of Notch1 in adult epidermis and cornea leads to epithelial hyperthickening accompanied by expansion of basal layers (Rangarajan et al., 2001).”
• The role of Notch in tumorigenesis: oncogene or tumour suppressor? (2003, background): “cgi?l=12575">Waf1 (also known as Cip1 and p21) in primary mouse keratinocyte”
• Getting under the skin of epidermal morphogenesis (2002, neutral): “Consistent with this idea is the finding that the conditional ablation of Notch1 in mouse skin epithelia results in epidermal hyperproliferation and reduced differentiatio”
• When NRF2 Talks, Who's Listening? (2010, neutral): “Interestingly, NOTCH signaling induces terminal differentiation to activate p21 gene expression directly in keratinocytes (118, 158).”